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polydeoxyadenylic acid-polythymidylic acid

double-stranded homopolymer; RN refers to sodium salt

Also Known As:

poly (dA).poly (dT)

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 15763
  - Polynucleotides: 218
    - Polydeoxyribonucleotides: 105
      - polydeoxyadenylic acid-polythymidylic acid: 5

Experts

1.	Mukumoto, Kosuke: 1 article (03/2006)
2.	Nojima, Takahiko: 1 article (03/2006)
3.	Ohtsuka, Keiichi: 1 article (03/2006)
4.	Takenaka, Shigeori: 1 article (03/2006)

Related Diseases

1.	Dehydration (Water Stress) 07/26/1994 - "On the basis of apparent molar volume, phi V, and apparent molar adiabatic compressibility, phi Ks, values for the initial drug-free and final drug-bound states of the two all-AT duplexes, we propose that the larger dehydration of the poly(dA).poly(dT) duplex reflects, in part, the formation of a less hydrated poly(dA).poly(dT)-netropsin complex compared with the corresponding poly(dAdT).poly(dAdT)-netropsin complex. " 07/26/1994 - "When netropsin binds to the poly(dT).poly(dA).poly(dT) triplex, the changes in both volume and compressibility suggest that the binding event induces more dehydration of the triplex than of the duplex state. " 06/12/1989 - "The following conclusions have been made: (1) the hydration of the double helix of poly(dA).poly(dT) is remarkably larger than that of other polynucleotides; (2) the hydration of the AT pair in the B-form DNA is larger than that of the GC pair; (3) the substitution of Cs+ for Mg2+ ions as counter ions results in a decrease of hydration of the system polynucleotide plus Mg2+, and (4) the magnitude of this dehydration depends on the nucleotide sequence; the following rule is true: the lesser is a polynucleotide hydration, the larger dehydration upon changing Cs+ for Mg2+ ions in the ionic atmosphere of polynucleotide."
2.	Poisoning 04/01/1996 - "We have used a broad range of spectroscopic and viscometric techniques to demonstrate that the complexation of a cytotoxic, topoisomerase I-poisoning terbenzimidazole (5PTB) with the poly(dA).poly(dT) duplex exhibits properties characteristic of both intercalation and minor groove binding. "
3.	Neoplasms (Cancer) 09/01/1976 - "If DNase I activity could be related to serum DNase and DNase II related to tumor lyososomal DNase as in the endocytosis mechanism proposed by Trouet et al. (Cancer Chemotherapy Rept., 59: 260, 1975), the best adriamycin carrier suggested by this investigation could be poly(dA)-poly(dT) and poly(dG-dC). "
4.	Skeletal Abnormalities Mandibular Hypoplasia Auditory Canal Atresia Short Stature 03/01/2006 - "When treated with poly(dT), poly(dA), or poly(dA)poly(dT), only poly(dT) was immobilized on the surface of the SAMs through a specific reaction of the free imino moiety of thymine (T) with the carbodiimide moiety. "

Related Drugs and Biologics

1.	Poly T
2.	B-Form DNA (B-DNA)
3.	Thymine
4.	Polynucleotides
5.	Netropsin
6.	Ions
7.	Doxorubicin (Adriamycin)
8.	Type I DNA Topoisomerases (Topoisomerase I)
9.	Deoxyribonucleases (DNase)
10.	Deoxyribonuclease I (Nickase)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)