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pronethalol (pronetalol)

was heading 1964-94 (Prov 1964-66); NAPHTHYLISOPROTERENOL was see PRONETHALOL 1977-94; use ETHANOLAMINES to search PRONETHALOL 1966-94
Also Known As:
pronetalol; naphthylisoproterenol; 2-Naphthalenemethanol, alpha-(((1-methylethyl)amino)methyl)-
Networked: 23 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1. Angina Pectoris
2. Contracture
3. Cardiac Arrhythmias (Arrythmia)
4. Ganglion Cysts (Ganglion)
08/01/1964 - "This relaxation was inhibited by pronethalol or physostigmine but no contractile component to ganglion stimulation was revealed when these two drugs were present together. "
05/01/1970 - "With trains of ten or more pulses, response A is always larger than B; the ratio of A/B (1.2-21.3) is subject to animal variation.2. Both responses are abolished by tetrodotoxin and are absent from plexus-free preparations.3. Neither response is reduced by ganglion-block with (+)-tubocurarine, dimethyltubocurarine or hexamethonium, or by ganglion-paralysing doses of nicotine; the contribution of excited preganglionic endings to these responses is therefore negligible.4. Neither response is due to a release of histamine, 5-hydroxytryptamine (5-HT) or prostaglandins, since both A and B persist in the presence of mepyramine, methysergide and the prostaglandin-antagonist SC-19220 (1-acetyl-2(8-chloro-10,11-dihydrodibenz [b,f] [1,4]oxazepine-10-carbonyl) hydrazine).5. The two response-components are affected differentially by a number of drugs.6. Histamine, 0.1 mug/ml., reduces response A to the level of B; this selective inhibition of the histamine-sensitive component in A is specifically antagonized by nicotine, 1-2.5 x 10(-5) g/ml.7. 5-HT, 0.1 mug/ml., and strychnine, 20-40 mug/ml., also reduce response A to the level of B, but these selective inhibitions are not antagonized by nicotine.8. Diphenhydramine, 10 mug/ml., produces equality of the two responses by depressing A and potentiating B.9. The inhibitory effects of the foregoing drugs are not due to catecholamine release, since they persist after alpha + beta adrenoceptor blockade with phentolamine and pronethalol, and after previous reserpinization of the guinea-pigs.10. "
5. Hemorrhagic Shock

Related Drugs and Biologics

1. Phentolamine (Z-Max)
2. Norepinephrine (Noradrenaline)
3. Reserpine (Serpasil)
4. Ouabain (G Strophanthin)
5. Histamine (Histamine Dihydrochloride)
6. Hexamethonium (Hexamethonium Bromide)
7. Potassium
8. Pentobarbital (Nembutal)
9. Nicotine
10. Isoproterenol (Isoprenaline)

Related Therapies and Procedures

1. Intraventricular Injections
2. Injections