pronethalol (pronetalol)

01/01/1968 - "Pronethalol-induced ultra-low frequency ballistocardiographic alterations in a patient with angina pectoris."
11/16/1963 - "EFFECT OF PRONETHALOL IN ANGINA PECTORIS."
05/09/1964 - "PRONETHALOL ("ALDERLIN") A BETA ADRENERGIC INHIBITOR: PHARMACOLOGICAL OBSERVATIONS AND TRIAL IN ANGINA PECTORIS."

07/01/1968 - "A similar time course has been found for the effect of adrenaline on membrane potential.6. Pronethalol blocks the action of adrenaline on both twitch and contracture. "
06/01/1973 - "This relaxation is not influenced by atropine or pronethalol.4. When sodium is totally excluded from the bathing medium the rate of relaxation of a later potassium contracture is much increased. "
07/01/1968 - "The action on the contracture can also be blocked by ouabain (1 x 10(-5)M), and exposure of the tissue to K-free or Na-free Ringer solution.7. Adrenaline hyperpolarizes the membrane potential with a range of [K](o) from 0 to 200 mM. This effect is blocked by pronethalol and ouabain. "
02/01/1967 - "This action on potassium permeability was abolished by the alpha-blocking agent phentolamine (10(-7) g/ml.), the beta-blocking agent pronethalol (10(-7) g/ml.) being without effect.3. In contrast, isoprenaline was about 30 times more active than noradrenaline in inhibiting calcium contractures of the depolarized taenia, suggesting that here the beta-receptors were concerned. "
02/01/1967 - "This was confirmed by showing that this action of noradrenaline was effectively antagonized by pronethalol, again at 10(-7) g/ml., but not by the same concentration of phentolamine.4. Carbachol contractures in quiescent preparations bathed in Krebs solution at 17 degrees C could be inhibited by both noradrenaline and isoprenaline. "

05/14/1966 - "Antagonism of digitalis arrhythmia by pronethalol: a neural phenomenon?"
04/01/1965 - "THE EFFECTS OF PRONETHALOL AND ITS DEXTRO ISOMER UPON EXPERIMENTAL CARDIAC ARRHYTHMIAS."
09/01/1966 - "Effect of quinidine and pronethalol on acetylstrophanthidin-induced ventricular arrhythmia in cats treated with reserpine."

08/01/1964 - "This relaxation was inhibited by pronethalol or physostigmine but no contractile component to ganglion stimulation was revealed when these two drugs were present together. "
05/01/1970 - "With trains of ten or more pulses, response A is always larger than B; the ratio of A/B (1.2-21.3) is subject to animal variation.2. Both responses are abolished by tetrodotoxin and are absent from plexus-free preparations.3. Neither response is reduced by ganglion-block with (+)-tubocurarine, dimethyltubocurarine or hexamethonium, or by ganglion-paralysing doses of nicotine; the contribution of excited preganglionic endings to these responses is therefore negligible.4. Neither response is due to a release of histamine, 5-hydroxytryptamine (5-HT) or prostaglandins, since both A and B persist in the presence of mepyramine, methysergide and the prostaglandin-antagonist SC-19220 (1-acetyl-2(8-chloro-10,11-dihydrodibenz [b,f] [1,4]oxazepine-10-carbonyl) hydrazine).5. The two response-components are affected differentially by a number of drugs.6. Histamine, 0.1 mug/ml., reduces response A to the level of B; this selective inhibition of the histamine-sensitive component in A is specifically antagonized by nicotine, 1-2.5 x 10(-5) g/ml.7. 5-HT, 0.1 mug/ml., and strychnine, 20-40 mug/ml., also reduce response A to the level of B, but these selective inhibitions are not antagonized by nicotine.8. Diphenhydramine, 10 mug/ml., produces equality of the two responses by depressing A and potentiating B.9. The inhibitory effects of the foregoing drugs are not due to catecholamine release, since they persist after alpha + beta adrenoceptor blockade with phentolamine and pronethalol, and after previous reserpinization of the guinea-pigs.10. "

07/01/1970 - "Effect of pronethalol on left ventricular volumes of dogs during hemorrhagic shock."
04/01/1967 - "Prevention of myocardial lesions during hemorrhagic shock in dogs by pronethalol."