bucolome

was heading 1978-94 (see under BARBITURATES 1978-90); was PARAMIDINE see under BARBITURATES 1975-77; use BARBITURATES to search BUCOLOME 1978-94 & PARAMIDINE 1975-77; proposed anti-inflammatory agent with possible analgesic properties

Also Known As:

1-cyclohexyl-5-butylbarbituric acid; Paramidine; 2,4,6(1H,3H,5H)-Pyrimidnetrione, 5-butyl-1-cyclohexyl-

Networked: 14 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - Barbiturates: 1074
        bucolome: 14

Experts

1.	Hirakawa, Masaaki: 1 article (11/2021)
2.	Ieiri, Ichiro: 1 article (11/2021)
3.	Kurinami, Miho: 1 article (11/2021)
4.	Miyazu, Daisuke: 1 article (11/2021)
5.	Tateishi, Hiroki: 1 article (11/2021)
6.	Watanabe, Hiroyuki: 1 article (11/2021)
7.	Aizawa, Yoshifusa: 1 article (01/2011)
8.	Hanawa, Haruo: 1 article (01/2011)
9.	Hirono, Satoru: 1 article (01/2011)
10.	Ito, Masahiro: 1 article (01/2011)

Related Diseases

1.	Kernicterus 08/01/1982 - "When kernicterus was induced in jaundiced rats by an injection of bucolome, the NSE level in cerebrospinal fluid was elevated up to more than 30-fold the control, together with a significantly higher level of alpha gamma form in blood plasma are helpful in detecting neuronal damage in the central nervous system." 11/26/1977 - "Induction of kernicterus by bucolome in rats." 06/01/1978 - "It is suggested that bucolome displaces bilirubin from albumin, transferring bilirubin from blood into tissues including the brain, and resulting in kernicterus. "
2.	Heart Diseases (Heart Disease) 04/01/2001 - "The objective of this study was to investigate the stereoselective influence of bucolome on the pharmacokinetics and pharmacodynamics of warfarin in Japanese inpatients with heart disease. "
3.	Chronic Hepatitis C 11/30/2008 - "A 31-year-old man had been treated with carbamazepine (CBZ) for 6 years and warfarin with bucolome for 2 years before developing hyponatremia 7 days after an injection of interferon-alpha 2b and starting oral ribavirin for chronic hepatitis C virus infection. "
4.	Disease Progression 11/03/2021 - "Based on the clinical course and literature review, we believe that hypoglycemia in the present case was due to a drug interaction, caused by inhibition of CYP2C9 by bucolome and competitive inhibition of CYP2C9 by warfarin, which affected the pharmacokinetics of glimepiride. "
5.	Weight Gain 07/01/1977 - "No sedation or drowsiness was observed in the infants given bucolome, and though the drug caused some vomiting, weight gains were unaffected."

Related Drugs and Biologics

1.	Warfarin (Coumadin)
2.	Bilirubin
3.	Albumins
4.	Cytochrome P-450 CYP2C9
5.	Interferon-alpha (Interferon Alfa)
6.	Vitamins
7.	Ribavirin (Virazole)
8.	Pyridoxine (Pyridoxin)
9.	Ouabain (G Strophanthin)
10.	Kinins

Related Therapies and Procedures

1.	Therapeutics
2.	Intravenous Injections