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1- (2- deoxy- 2- fluoro- 3- O- (1- methyl- 1,4- dihydropyridyl- 3- carbonyl)ribofuranosyl)- 5- (2- iodovinyl)uracil

structure given in first source; IVFRU coupled to a salt redox delivery system to increase diffusion into central nervous system

Also Known As:

IVFRU-CDS

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.

Carcinoma (Carcinomatosis)

07/01/1995 - "(E)-5-(2-Iodovinyl)-2'-deoxyuridine (IVDU), its 2'-fluoro-substituted derivatives IVFRU (with fluorine in the ribo configuration), IVFAU (with fluorine in the ara configuration), and the corresponding 3'-chemical delivery system (CDS), or 3'-O-(1-methyl-1,4-dihydropyridyl-3-carbonyl)- substituted derivatives IVDU-CDS, IVFRU-CDS and IVFAU-CDS were evaluated for their cytostatic activity against wild-type (FM3A/O), thymidine kinase (TK)-deficient (FM3A/TK-), and herpes simplex virus type 1 (HSV-1) or HSV-2 thymidine kinase (tk) gene-transfected murine mammary carcinoma FM3A cells (FM3A TK-/HSV-1 TK+ and FM3A TK-/HSV-2 TK+). "

Related Drugs and Biologics

1.	Cytostatic Agents
2.	Thymidine Kinase
3.	Fluorine
4.	5- (2- iodovinyl)- 1- (2'- fluoro- 2'- deoxyuridine)