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DV 7751a
a fluoroquinolone with an aminopyrrolidine substituent at the C-10 position of the benzoxazine skeleton; structure given in first source
Also Known As:
DV 7751; DV-7751; DV-7751a; 7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 10-(8-amino-6-azaspiro(3.4)oct-6-yl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (S-(R*,R*))-
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Quinolines: 146
Quinolones: 2938
Fluoroquinolones: 5348
DV 7751a: 3
Related Diseases
1.
Phototoxic Dermatitis (Phototoxicity)
06/01/1996 - "
DV-7751a showed very weak phototoxicity in mice after single oral administration of 600 mg/kg, followed by UVA irradiation, but no convulsion after oral administration of 200 or 1000 mg/kg in combination with 4-biphenylacetic acid at 400 mg/kg.
"
2.
Vomiting
06/01/1996 - "
A single oral administration of DV-7751a induced soft stool in rats at 1000 and 2000 mg/ kg and in monkeys at 250 mg/kg and vomiting in monkeys at 500 mg/kg or more.
"
3.
Joint Diseases (Joint Disease)
09/01/1997 - "
In immature dogs (n = 3) orally given DV-7751a at 5, 10 and 15 mg/kg for 8 days, arthropathy in the femur of a dog receiving 15 mg/kg was observed at termination, but not at the lower doses.
"
4.
Infections
07/01/1995 - "
DV-7751a appears to be a candidate for the therapy of some mixed-flora infections and the treatment of bacteria resistant to the current fluoroquinolones.
"
5.
Diarrhea
09/01/1997 - "
In mature monkeys (n = 3) treated orally with DV-7751a at 100 mg/kg for 14 days, no toxic effects were found except for mild diarrhea throughout the experiment.
"
Related Drugs and Biologics
1.
Fluoroquinolones
2.
Acids
Related Therapies and Procedures
1.
Therapeutics
2.
Oral Administration