Progranulins

Cysteine-rich, precursor glycoproteins encoded by the granulin gene (GRN). They contain granulin-repeats separated by linker sequences that are cleaved by a variety of proteases to release the individual GRANULIN PEPTIDES. The mammalian progranulin is composed of a half-granulin repeat followed by 7 granulin repeats. The mammalian GRANULINS are named PARAGRANULIN and granulin 1-7 for their order in the progranulin propeptide. Progranulin has growth-factor like effects and is expressed over a broad range of tissues. Under-expression of progranulin is linked to neurodegenerative diseases including FRONTOTEMPORAL DEMENTIA and NEURONAL CEROID LIPOFUSCINOSIS, while over-expression is linked to metabolic diseases including OBESITY, and INSULIN RESISTANCE.

Also Known As:

Acrogranin; Granulin Precursor; Granulin Precursor Protein; PC Cell-Derived Growth Factor; Proepithelin; Progranulin; PC Cell Derived Growth Factor

Hormones, Hormone Substitutes, and Hormone Antagonists
- Hormones: 80400
  - Peptide Hormones: 1347
    - Progranulins: 1142
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intercellular Signaling Peptides and Proteins: 29768
    - Progranulins: 1142
  - Protein Precursors: 37
    - Progranulins: 1142
- Peptides: 82426
  - Intercellular Signaling Peptides and Proteins: 29768
    - Progranulins: 1142
Biological Factors: 2472
- Intercellular Signaling Peptides and Proteins: 29768
  - Progranulins: 1142

rat Grn protein

Bio-Agent Context: Research Results