integrin alpha9

associates principally with the integrin beta(1) subunit; detected in human carcinoma cell lines, Tera-2 and Caco-2; has 1006 amino acid residues; shares 39% identity with integrin alpha4; amino acid sequence given in first source; GenBank L24158; likely to be designated future CD Antigen

Also Known As:

Networked: 17 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kon, Shigeyuki: 2 articles (06/2010 - 06/2009)
2.	Kurotaki, Daisuke: 2 articles (06/2010 - 06/2009)
3.	Matsui, Yutaka: 2 articles (06/2010 - 06/2009)
4.	Morimoto, Junko: 2 articles (06/2010 - 06/2009)
5.	Nakayama, Yosuke: 2 articles (06/2010 - 06/2009)
6.	Uede, Toshimitsu: 2 articles (06/2010 - 06/2009)
7.	Andrews, Melissa R: 2 articles (02/2010 - 04/2009)
8.	Blits, Bas: 2 articles (02/2010 - 04/2009)
9.	Faissner, Andreas: 2 articles (02/2010 - 04/2009)
10.	Fawcett, James W: 2 articles (02/2010 - 04/2009)

Related Diseases

1.	Arthritis (Polyarthritis) 06/15/2009 - "Thus, we identified alpha(9) integrin as a critical intrinsic regulator that controls the development of autoimmune arthritis." 06/15/2009 - "Alpha9 integrin and its ligands constitute critical joint microenvironments for development of autoimmune arthritis." 06/15/2009 - "Inhibition of alpha(9) integrin function with an anti-alpha(9) integrin Ab significantly reduces the production of arthrogenic cytokines and chemokines and ameliorates ongoing arthritis. "
2.	Wounds and Injuries (Trauma) 06/01/2010 - "In conclusion, alpha9 integrin is involved in the formation of granulation tissue through regulating migration and adhesion of dermal fibroblasts in the full-thickness skin excisional wound model." 06/01/2010 - "Recently, alpha9 integrin has also been detected on keratinocytes within wound sites. " 06/01/2004 - "Small wounds never showed differences in the localization of alpha9 integrin at the limbus, and no goblet cells were observed in the central cornea. " 06/01/2004 - "Large wounds often resulted in the presence of goblet cells on the central cornea and a loss of alpha9 integrin at the limbus. " 06/01/2004 - "With large wounds, RCES corneas frequently showed numerous goblet cells adjacent to a limbus lacking alpha9 integrin. "
3.	Neoplasms (Cancer) 07/01/1999 - "In some areas of SCC, alpha9 integrin localized throughout all cell layers of the tumor epithelium. " 09/01/2011 - "Integrin alpha9 (ITGA9) is one of the less studied integrin subunits that facilitates accelerated cell migration and regulates diverse biological functions such as angiogenesis, lymphangiogenesis, cancer cell proliferation and migration. " 10/01/2005 - "In attachment assays, the recombinant disintegrin domain of ADAM12 only supported alpha9 integrin-dependent tumor cell attachment, whereas full-length ADAM12 supported attachment via alpha9 integrin and other integrin receptors. "
4.	Spinal Cord Injuries (Spinal Cord Injury) 04/29/2009 - "Behavioral analysis after spinal cord injury revealed that both experimental and control groups had an increased withdrawal latency in response to mechanical stimulation when compared with sham controls; however, in response to heat stimulation, normal withdrawal latencies returned after alpha9 integrin treatment but remained elevated in control groups."
5.	Rhabdomyosarcoma 10/11/2022 - "Integrin alpha9 emerges as a key therapeutic target to reduce metastasis in rhabdomyosarcoma and neuroblastoma."

Related Drugs and Biologics

1.	Integrins
2.	Chemokines
3.	Cytokines
4.	Tenascin
5.	Proteins (Proteins, Gene)
6.	Ligands
7.	Messenger RNA (mRNA)
8.	Syndecan-1 (Syndecan 1)
9.	Disintegrins
10.	Retinal Pigments (Pigments, Visual)

Related Therapies and Procedures

1.	Debridement
2.	Immunomodulation
3.	Dermabrasion