clotiazepam

was heading 1975-94 (see under AZEPINES 1978-90; was Y 6047 see under AZEPINES 1975-77); Y 6047 was see CLOTIAZEPAM 1978-94; use AZEPINES to search CLOTIAZEPAM 1975-94; thienodiazepine derivative with actions similar to those of benzodiazepines

Also Known As:

Y 6047; Y-6047; Y6047; 2H-Thieno(2,3-e)-1,4-diazepin-2-one, 5-(2-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-

Networked: 12 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azepines: 11
    - clotiazepam: 12

Experts

1.	Miyamatsu, Yayoi: 1 article (08/2021)
2.	Tanizaki, Ryutaro: 1 article (08/2021)
3.	Ao, Lin: 1 article (01/2020)
4.	Horiguchi, Saki: 1 article (01/2020)
5.	Ikarashi, Takumi: 1 article (01/2020)
6.	Matsuo, Kazuhiro: 1 article (01/2020)
7.	Obara, Keisuke: 1 article (01/2020)
8.	Ogawa, Tsukasa: 1 article (01/2020)
9.	Shimada, Toma: 1 article (01/2020)
10.	Tanaka, Yoshio: 1 article (01/2020)

Related Diseases

1.	Fibrosis (Cirrhosis) 01/01/1986 - "Thus cirrhosis is associated with reduced clearance of clotiazepam, probably due to impairment of its microsomal oxidation. " 01/01/1986 - "Effect of cirrhosis and renal failure on the kinetics of clotiazepam." 01/01/1986 - "The kinetics of a single 5-mg oral dose of the thienodiazepine clotiazepam was evaluated in a series of patients with biopsy-proven cirrhosis, and in patients with renal insufficiency requiring maintenance hemodialysis, compared to healthy matched controls. "
2.	Psychophysiologic Disorders (Psychosomatic Disorders) 10/11/1979 - "The efficacy and the compatibility of the new anxiolytic Trecalmo (Clotiazepam) were investigated by means of a field trial covering 186 patients, suffering from anxiety and tension as well as from psychosomatic disorders. "
3.	Cardiovascular Diseases (Cardiovascular Disease) 01/01/1990 - "In a phase IV study with clotiazepam 9 cardiologists were involved to treat 86 patients (52 female, 32 male, mean age 51 years) effected by cardiovascular diseases and anxiety. "
4.	Stomach Ulcer (Gastric Ulcer) 04/01/1984 - "Clotiazepam prevented the development of each gastric ulcer. " 12/01/1987 - "These results suggest that clotiazepam has a suppressive action against gastric ulcers produced by non-physical or physical stimuli, although its potency is slightly weaker than that of diazepam." 12/01/1987 - "The incidence of gastric ulcers was suppressed by clotiazepam at a dose of 3 mg/kg, per os, in "responder" and "sender" mice, and by diazepam at a dose of 1 mg/kg, per os, in "responder" mice. "
5.	Renal Insufficiency (Renal Failure) 01/01/1986 - "However clotiazepam disposition is not significantly altered in dialysis-dependent renal insufficiency patients." 01/01/1986 - "There were no significant differences between renal failure and control patients in clotiazepam Vz, oral clearance, or elimination half-life. " 01/01/1986 - "Effect of cirrhosis and renal failure on the kinetics of clotiazepam." 01/01/1986 - "The kinetics of a single 5-mg oral dose of the thienodiazepine clotiazepam was evaluated in a series of patients with biopsy-proven cirrhosis, and in patients with renal insufficiency requiring maintenance hemodialysis, compared to healthy matched controls. "

Related Drugs and Biologics

1.	Anti-Anxiety Agents (Anxiolytics)
2.	Diazepam (Valium)
3.	Adrenergic Agents (Adrenergic Drugs)
4.	Viloxazine
5.	Benzodiazepines

Related Therapies and Procedures

1.	Renal Dialysis (Hemodialysis)