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didodecyl N- (alpha- trimethylammonioacetyl)glutamate

used in preparing cationic multilamellar vesicles

Also Known As:

N-(alpha-trimethylammonioacetyl)-didodecyl-D-glutamate chloride; TMAG cpd; didodecyl 3MeNAcGlu

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Acidic Amino Acids: 44
    - Glutamates: 45
      - didodecyl N-(alpha-trimethylammonioacetyl)glutamate: 5
  - Dicarboxylic Amino Acids: 20
    - Glutamates: 45
      - didodecyl N-(alpha-trimethylammonioacetyl)glutamate: 5

Experts

1.	Mizuno, Masaaki: 1 article (10/2002)
2.	Ryuke, Yasushi: 1 article (10/2002)
3.	Yoshida, Jun: 1 article (10/2002)
4.	Aoki, H: 1 article (11/2001)
5.	Mizuno, M: 1 article (11/2001)
6.	Natsume, A: 1 article (11/2001)
7.	Takahashi, T: 1 article (11/2001)
8.	Tsugawa, T: 1 article (11/2001)
9.	Tsujimura, K: 1 article (11/2001)
10.	Yoshida, J: 1 article (11/2001)

Related Diseases

1.	Glioma (Gliomas) 10/01/2002 - "Our original liposomes consist of N-(alpha-trimethylammonioacetyl)-didodecyl-D-glutamate chloride, dilauroyl phosphatidylcholine, and dioleoyl phosphatidyl-ethanolamine in a molar ratio of 1:2:2. AxCAHSV-tk and GCV showed a remarkable inhibition of experimental glioma growth. " 05/01/1992 - "The liposomes were composed of N-(alpha -trimethylammonioacetyl) -didodecyl-D-glutamate chloride (TMAG), dilauroylphosphatidylcholine (DLPC), and dioleoylphosphatidylethanolamine (DOPE) as a molar ratio of 1:2:3. The liposomes were not observed to have cytotoxicity for human glioma cells, when applied at a rate less than 15nmol/ml. This liposome-mediated transfection of the gene into the cultured glioma cells (U-251-MG) resulted in the secretion of HuIFN- beta into the medium. " 11/01/2001 - "As a liposome, we used cationic small unilamellar vesicles composed of N-(alpha-trimethylammonioacetyl)-didodecyl-D-glutamate chloride (TMAG), dilauroylphosphatidylcholine (DLPC), and dioleoylphosphatidylethanolamine (DOPE) in a molar ratio of 1:2:2. After intracerebral inoculation of mouse malignant glioma GL261 cells into syngeneic C57BL/6 mice, DCs pulsed with extract from the glioma cells by sonication were administered intraperitoneally thrice weekly on days 7, 14 and 21. "
2.	Neoplasms (Cancer) 07/01/1997 - "A plasmid pLTR-DT which contained a gene for diphtheria toxin A-chain (DT-A) under the control of the long terminal repeat (LTR) of bovine leukemia virus (BLV) (BLV-LTR) in the multicloning site of pUC-18 was entrapped in cationic liposomes composed of N-(alpha-trimethylammonioacetyl)-didodecyl-D-glutamate chloride (TMAG), dioleoyl phosphatidylethanolamine (DOPE) and dilauroyl phosphatidylcholine (DLPC) (1:2:2, molar ratio) (TMAG-liposome), and their antitumor effect on BLV-infected tumor cells was examined in vivo. " 01/01/1994 - "When plasmid pSV2IFN-beta, bearing the human interferon-beta gene, was encapsulated into cationic multilamellar liposomes composed of N-(alpha-trimethylammonioacetyl)-didodecyl-D-glutamate chloride, dilauroyl phosphatidylcholine, and dioleoyl phosphatidylethanolamine in a molar ratio of 1:2:2 and injected intratumorally, human interferon-beta was produced in the tumor. "

Related Drugs and Biologics

1.	Liposomes (Liposome)
2.	dioleoyl phosphatidylethanolamine
3.	Phosphatidylcholines (Phosphatidylcholine)
4.	1,2-dilauroylphosphatidylcholine
5.	Unilamellar Liposomes
6.	Ethanolamine (Colamine)
7.	Interferon-beta
8.	diphtheria toxin fragment A