AFAP 110

a tyrosine-phosphorylated protein; forms a stable complex with activated pp60(src) protein; AFAP-120 is a larger variant of AFAP-110; amino acid sequence given in first source; GenBank L20303

Also Known As:

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Flynn, Daniel C: 3 articles (08/2010 - 10/2007)
2.	Dorfleutner, Andrea: 2 articles (12/2007 - 10/2007)
3.	Gallick, Gary E: 2 articles (12/2007 - 10/2007)
4.	Zhang, Jing: 2 articles (12/2007 - 10/2007)
5.	Bourguignon, Lilly Y W: 1 article (12/2011)
6.	Earle, Christine A: 1 article (12/2011)
7.	Wong, Gabriel: 1 article (12/2011)
8.	Xia, Weiliang: 1 article (12/2011)
9.	Cho, Youngjin: 1 article (08/2010)
10.	Clump, Anne C: 1 article (08/2010)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 12/01/2011 - "Our data indicate that LMW-HA (but not HMW-HA) preferentially stimulates a physical association between CD44 and TLRs followed by a concomitant recruitment of AFAP-110 and MyD88 into receptor-containing complexes in breast tumor cells. " 12/01/2007 - "In summary, AFAP-110 plays an important role in MDA-MB-231 breast cancer cell adhesion possibly by regulating stress filament cross-linking which would promote focal adhesion formation." 12/01/2007 - "An inducible knockdown approach confirms that MDA-MB-231 breast cancer cells require AFAP-110 expression for stress fiber formation and adhesion. " 12/01/2007 - "Screening of different breast epithelial cell lines revealed high expression levels of AFAP-110 in the human breast cancer cell lines MDA-MB-231 and MDA-MB-435. " 12/01/2007 - "AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells."
2.	Prostatic Neoplasms (Prostate Cancer) 10/01/2007 - "Thus, increased expression of AFAP-110 is associated with progressive stages of prostate cancer and is critical for tumorigenic growth, in part by regulating focal contacts in a PKC-dependent mechanism." 10/01/2007 - "Downregulation of AFAP-110 in PC3 prostate cancer cells inhibited cell proliferation in vitro and tumorigenicity and growth in orthotopic nude mouse models. " 10/01/2007 - "AFAP-110 is overexpressed in prostate cancer and contributes to tumorigenic growth by regulating focal contacts."
3.	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 10/01/2007 - "Using immunohistochemistry of human tissue arrays, we found that AFAP-110 was absent or expressed at very low levels in normal prostatic epithelium and benign prostatic hyperplasia but significantly increased in prostate carcinomas. "
4.	Ovarian Neoplasms (Ovarian Cancer) 08/01/2010 - "Immunohistochemical analysis revealed a concomitant increase of AFAP-110 and cSrc in ovarian cancer tissues. " 08/01/2010 - "In this report, we analyzed ovarian cancer tissues for the expression of a cSrc-activating protein, AFAP-110. "
5.	Carcinoma (Carcinomatosis) 10/01/2007 - "The level of AFAP-110 in carcinomas correlated with the Gleason scores. " 10/01/2007 - "Here we investigated the roles of AFAP-110 in the tumorigenic process of prostate carcinoma. " 10/01/2007 - "Using immunohistochemistry of human tissue arrays, we found that AFAP-110 was absent or expressed at very low levels in normal prostatic epithelium and benign prostatic hyperplasia but significantly increased in prostate carcinomas. "

Related Drugs and Biologics

1.	Small Interfering RNA (siRNA)
2.	Proteins (Proteins, Gene)