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1- methyl- 1- phenyl- 1,2,3,4- tetrahydroisoquinoline
structure given in first source; a non-competitive NMDA receptor antagonist; RN refers to (+)-isomer
Also Known As:
1-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline, (-)-isomer; FR 115427; FR-115427; FR115427
Networked:
4
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Isoquinolines: 34
Tetrahydroisoquinolines: 44
1-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline: 4
Related Diseases
1.
Ischemia
03/01/1994 - "
FR115427 prevented hippocampal CA1 cell damage at a dose of 10 mg/kg and reduced spontaneous locomotor hyperactivity in gerbils after the development of ischemia at a dose of 32 mg/kg. The effective doses of MK801 were 3.2 mg/kg for preventing hippocampal CA1 cell damage and 1 mg/kg for reducing spontaneous locomotor hyperactivity.
"
03/01/1995 - "
FR115427 (10 mg/kg, i.p.) significantly improved neurologic deficit at 1 day after ischemia and reduced total infarct volume (54%) at 7 days after ischemia.
"
01/01/1996 - "
Among these compounds, (+)-1-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride ((+)-1a, FR115427) was the most effective anticonvulsant, and also protected CA1 hippocampal neurons from ischemia-induced neuronal degeneration in rats at 32 mg/kg i.p.
"
2.
Stroke (Strokes)
03/01/1995 - "
These results suggest that FR115427 may be useful in the treatment of stroke.
"
3.
Neurologic Manifestations (Neurological Manifestations)
03/01/1995 - "
FR115427 (10 mg/kg, i.p.) significantly improved neurologic deficit at 1 day after ischemia and reduced total infarct volume (54%) at 7 days after ischemia.
"
4.
Infarction (Infarctions)
03/01/1995 - "
FR115427 (10 mg/kg, i.p.) significantly improved neurologic deficit at 1 day after ischemia and reduced total infarct volume (54%) at 7 days after ischemia.
"
5.
Brain Ischemia (Cerebral Ischemia)
03/01/1995 - "
The neuroprotective effect of the novel noncompetitive NMDA antagonist, FR115427 in focal cerebral ischemia in rats.
"
03/01/1995 - "
The present study was carried out to compare the neuroprotective effect of the novel noncompetitive NMDA antagonist, FR115427, with that of(+)MK-801 in rat focal cerebral ischemia.
"
Related Drugs and Biologics
1.
Dizocilpine Maleate (Dizocilpine)
2.
N-Methylaspartate (NMDA)
3.
Neuroprotective Agents
4.
Anticonvulsants (Antiepileptic Drugs)
5.
Thiophenes
6.
Pyridines
7.
Benzene (Benzole)
8.
benzothiophene
9.
furan
10.
indole