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2-phenyl-4-oxohydroquinoline

structure given in first source

Also Known As:

2-phenyl-4-quinolone; YT-1 compound

Networked: 9 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Quinolones: 2938
        2-phenyl-4-oxohydroquinoline: 9

Experts

1.	Kuo, Sheng-Chu: 8 articles (03/2018 - 07/2005)
2.	Yang, Jai-Sing: 3 articles (03/2018 - 12/2009)
3.	Lee, Kuo-Hsiung: 3 articles (05/2011 - 07/2005)
4.	Ho, Chi-Tang: 2 articles (12/2016 - 04/2015)
5.	Hung, Chao-Ming: 2 articles (12/2016 - 04/2015)
6.	Lin, Ying-Chao: 2 articles (12/2016 - 04/2015)
7.	Way, Tzong-Der: 2 articles (12/2016 - 04/2015)
8.	Huang, Li-Jiau: 2 articles (05/2011 - 12/2009)
9.	Guh, Jih-Hwa: 2 articles (02/2008 - 06/2007)
10.	Huang, Yu-Chun: 2 articles (02/2008 - 06/2007)

Related Diseases

1.	Neoplasms (Cancer) 04/25/2015 - "In this study, we examined the anti-tumor effects of CHM-1, a synthetic 6,7-methylenedioxy substituted 2-phenyl-4-quinolone derivative, on GBM cells in vitro and in vivo. " 05/01/2011 - "2-Phenyl-4-quinolone series compounds have exhibited growth inhibitory influence on several human cancer cell lines. " 12/01/2009 - "Novel 2-phenyl-4-quinolone compounds have potent cytotoxic effects on different human cancer cell lines. " 07/15/2005 - "Cancer preventive agents, Part 2: Synthesis and evaluation of 2-phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives as novel antitumor promoters." 06/30/2007 - "2-Phenyl-4-quinolone displayed anti-proliferative effect in several cancer types, including hormone-resistant prostate cancer PC-3, hepatocellular carcinoma Hep3B and HepG2, non-small cell lung cancer A549 and P-glycoprotein-rich breast cancer NCI/ADR-RES cells. "
2.	Hepatocellular Carcinoma (Hepatoma) 02/01/2008 - "In this study, 2'-fluoro-6,7-methylenedioxy-2-phenyl-4-quinolone (CHM-1), a synthetic 6,7-substituted 2-phenyl-4-quinolone, was identified as a potent and selective antitumor agent in human hepatocellular carcinoma. " 06/30/2007 - "2-Phenyl-4-quinolone displayed anti-proliferative effect in several cancer types, including hormone-resistant prostate cancer PC-3, hepatocellular carcinoma Hep3B and HepG2, non-small cell lung cancer A549 and P-glycoprotein-rich breast cancer NCI/ADR-RES cells. "
3.	Prostatic Neoplasms (Prostate Cancer) 12/25/2016 - "CWF-145, a synthetic 2-phenyl-4-quinolone derivative exerted potent cytotoxicity against prostate cancer. " 06/30/2007 - "2-Phenyl-4-quinolone displayed anti-proliferative effect in several cancer types, including hormone-resistant prostate cancer PC-3, hepatocellular carcinoma Hep3B and HepG2, non-small cell lung cancer A549 and P-glycoprotein-rich breast cancer NCI/ADR-RES cells. "
4.	Leukemia 03/01/2018 - "2-Phenyl-4-quinolone (YT-1) induces G2/M phase arrest and an intrinsic apoptotic mechanism in human leukemia cells."
5.	Edema (Dropsy) 03/01/1994 - "Suppressive effect of 2-phenyl-4-quinolone (YT-1) on hind-paw edema and cutaneous vascular plasma extravasation in mice." 03/01/1994 - "Like indomethacin, BW755C, diphenhydramine and methysergide, 2-phenyl-4-quinolone (YT-1) suppressed the polymyxin B-induced hind-paw edema. "

Related Drugs and Biologics

1.	Antineoplastic Agents (Antineoplastics)
2.	2'- fluoro- 6,7- methylenedioxy- 2- phenyl- 4- quinolone
3.	Member 1 Subfamily B ATP Binding Cassette Transporter
4.	4,5- Dihydro- 1- (3- (trifluoromethyl)phenyl)- 1H- pyrazol- 3- amine
5.	Polymyxin B (Aerosporin)
6.	Methysergide (Sansert)
7.	Indomethacin (Indometacin)
8.	Hormones (Hormone)
9.	Diphenhydramine (Benadryl)
10.	9-oxo-9,10-dihydroacridine