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L 687414

RN given refers to (3S-cis)-isomer

Also Known As:

L 687,414; L 687414, (3R-cis)-isomer; L-687,414; L-687414; cis-4-methyl-HA-966

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - Pyrrolidinones: 162
      - L 687414: 4

Related Diseases

1.	Seizures (Absence Seizure) 11/01/1994 - "2. L-687,414 dose-dependently antagonized seizures induced by N-methyl-D,L- aspartic acid (NMDLA, ED50 = 19.7 mg kg-1), pentylenetetrazol (PTZ, ED50 = 13.0 mg kg-1) and electroshock (ED50 = 26.1 mg kg-1) when given intravenously 15 min before test, in male Swiss Webster mice but was most potent against audiogenic seizures induced by a 120 dB bell in DBA/2 mice (ED50 = 5.1 mg kg-1, i.p., 30 min before test). "
2.	Stroke (Strokes) 08/01/1998 - "LTP was effectively abolished in a separate group of rats treated with an MK-801 dosing regimen (0.12 mg kg(-1) i.v. followed by 1.8 microg kg(-1) h(-1)) known to produce maximal neuroprotection in a rat stroke model but, by contrast, remained largely intact in a third group of animals given a similarly neuroprotective L-687,414 treatment (28 mg kg(-1) i.v. followed by 28 mg kg(-1) h(-1)). "
3.	Inflammation (Inflammations) 04/01/1996 - "We have studied the effects on mechanical nociceptive thresholds in rats with carrageenin-induced paw inflammation of L-687,414, a low efficacy partial agonist which acts as a functional antagonist at the glycine modulatory site of the NMDA receptor and of L-701,324, a structurally novel, highly selective, full antagonist at this site. "
4.	Infarction (Infarctions) 03/01/1995 - "The lowest infusion dosing regimen of L-687,414 which gave a plasma level of 11 micrograms/ml over the 4 h was also ineffective against the volume of infarction measured in the different brain regions.(ABSTRACT TRUNCATED AT 250 WORDS)"
5.	Hyperalgesia 04/01/1996 - "3. Both compounds produced selective dose-dependent and statistically significant reversal of mechanical hyperalgesia, with minimum effective doses of 100 mg kg-1 L-687,414 and 3 mg kg-1 L-701,324. " 04/01/1996 - "Neither L-687,414 nor L-701,324 affected the response threshold of the contralateral non-inflamed paw over the dose-range producing reversal of carrageenin-induced hyperalgesia. "

Related Drugs and Biologics

1.	Pentylenetetrazole (Metrazol)
2.	Aspartic Acid (Aspartate)
3.	P-30 composite resin (P 30)
4.	Dizocilpine Maleate (Dizocilpine)
5.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
6.	Glycine (Aminoacetic Acid)
7.	Carrageenan
8.	L 701324