alcohol dehydrogenase (NAD(P)+)

reaction: an alcohol + NAD(P)+ = an aldehyde + NAD(P)H; inhibited by gossypol; short-chain dehydrogenase/reductase that reduces all-trans-retinal

Also Known As:

NADP-dependent alcohol dehydrogenase; alcohol:NAD(P)+ oxidoreductase; retSDR1; retinal reductase

Networked: 6 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Alcohol Oxidoreductases: 56
      - alcohol dehydrogenase (NAD(P)+): 6

Experts

1.	Ali, Robin R: 1 article (11/2019)
2.	Chen, Adrienne: 1 article (11/2019)
3.	Fahim, Abigail T: 1 article (11/2019)
4.	Feathers, Kecia L: 1 article (11/2019)
5.	Jia, Lin: 1 article (11/2019)
6.	Khan, Naheed W: 1 article (11/2019)
7.	Perera, Nirosha Dayanthi: 1 article (11/2019)
8.	Presswalla, Feriel K: 1 article (11/2019)
9.	Smith, Alexander J: 1 article (11/2019)
10.	Thompson, Debra A: 1 article (11/2019)

Related Diseases

1.	Retinal Degeneration 11/01/2019 - "In addition, administration of the vector reconstituted retinal reductase activity in the retinas of Rdh12-/- mice and decreased susceptibility to light damage associated with Rdh12 deficiency, thus demonstrating potential therapeutic efficacy in an animal model that does not exhibit a retinal degeneration phenotype. "
2.	Neoplasms (Cancer) 06/01/2010 - "Taken together, the results suggest a potential role of the p53/p63-mediated retSDR1 activation in tumor suppression as well as in developmental processes." 06/01/2010 - "A tumor-derived p53 mutant is unable to activate retSDR1 transcription. " 02/15/2002 - "Our observations suggest that retSDR1 is a novel regulator of vitamin A metabolism and that its frequent deletion in NB cells bearing MYCN amplification could compromise the sensitivity of those cells to retinol, thereby contributing to cancer development and progression." 06/01/2010 - "The retinal dehydrogenase/reductase retSDR1/DHRS3 gene is activated by p53 and p63 but not by mutants derived from tumors or EEC/ADULT malformation syndromes."
3.	Retinal Dystrophies 10/01/1981 - "Retinal reductase activity in rats with and without inherited retinal dystrophy."
4.	Neuroblastoma 02/15/2002 - "retSDR1, a short-chain retinol dehydrogenase/reductase, is retinoic acid-inducible and frequently deleted in human neuroblastoma cell lines."
5.	Inflammation (Inflammations) 09/01/2012 - "DHRS3, a retinal reductase, is differentially regulated by retinoic acid and lipopolysaccharide-induced inflammation in THP-1 cells and rat liver."

Related Drugs and Biologics

1.	Tretinoin (Retinoic Acid)
2.	Oxidoreductases (Dehydrogenase)
3.	Retinal Dehydrogenase
4.	Vitamin A (Retinol)
5.	Messenger RNA (mRNA)
6.	Proteins (Proteins, Gene)
7.	Lipopolysaccharides
8.	retinol dehydrogenase