laminin A

involved in diverse functions during morphogenesis in Drosophila and mammals; amino acid sequence given in first source; RefSeq NM_005559 (human), NM_008480 (mouse); GenBank M96388, L07288 and M75882 (Drosophila)

Also Known As:

LAMA protein, human; LAMA1 protein, human; Lama protein, mouse; Lama1 protein, mouse; Laminin A protein, Drosophila; Laminin alpha chain protein, Drosophila; LanA protein, Drosophila; alpha1 laminin; laminin alpha1; laminin, alpha 1 protein, human; laminin, alpha 1 protein, mouse

Networked: 135 relevant articles (1 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Jaeger, Ruy G: 3 articles (01/2010 - 07/2007)
2.	Durbeej, Madeleine: 3 articles (09/2006 - 08/2004)
3.	Kikkawa, Yamato: 2 articles (08/2012 - 12/2009)
4.	Nomizu, Motoyoshi: 2 articles (02/2010 - 12/2009)
5.	Gama-de-Souza, Letícia N: 2 articles (01/2010 - 06/2008)
6.	Pinheiro, João J V: 2 articles (01/2010 - 07/2007)
7.	Freitas, Vanessa M: 2 articles (06/2008 - 07/2007)
8.	Moriscot, Anselmo S: 2 articles (06/2008 - 07/2007)
9.	Vilas-Boas, Vanessa F: 2 articles (06/2008 - 07/2007)
10.	Kleinman, Hynda K: 2 articles (01/2008 - 06/2002)

Related Diseases

1.	Nephrosis 05/01/1991 - "In the remission stage of PAN nephrosis (on the 20th day), however, mRNA levels for alpha 1 (IV) chain and laminin A, B1, and B2 chains decreased, whereas mRNA levels for HSPG increased. " 05/01/1991 - "In the nephrotic stage of PAN nephrosis (on the 8th day), mRNA levels for alpha 1 (IV) chain and laminin A, B1, and B2 chains increased, whereas those for HSPG decreased. "
2.	Neoplasms (Cancer) 10/01/1999 - "During this process, the ability of tumor cells to adhere to laminin, a major component of basement membranes, is required at various steps. " 04/01/1999 - "We also tested 49 of the tumor specimens for the presence of laminin, a component of the BM, and found that in most of these 49 cases, the BM and PMFs co-existed. " 10/01/1994 - "Here we illustrate that laminin, a major component of basement membrane, has several biologically active sites that can bind to endothelial and tumor cells, and have the ability to regulate angiogenesis and tumor growth. " 01/01/1994 - "The consequences of the absence of laminin-A chain on basement membrane formation, cellular differentiation and tumor invasion will be currently determined." 01/01/1986 - "Two subunits of laminin, A and B, have been isolated and characterized from a variety of tumor matrices. "
3.	Neoplasm Metastasis (Metastasis) 09/01/1996 - "The elevated expression of alpha 6 beta 1 following malignant conversion of muscosal keratinocytes promotes their migration on laminin, a process important during invasion and metastasis." 01/01/1993 - "Interactions between cancer cells and laminin, a major component of basement membranes, play a critical role at several steps of the complex process of tumor invasion and metastasis. " 03/01/1991 - "Laminin, a major glycoprotein of basement membrane has been found to play significant roles during invasion and metastases. " 03/01/1990 - "Identification of an amino acid sequence from the laminin A chain that stimulates metastasis and collagenase IV production." 01/01/1989 - "Laminin, a basement membrane glycoprotein, has been implicated in a number of stages in tumour invasion and metastasis. "
4.	Fibrosis (Cirrhosis) 11/01/2006 - "Increases in the protein levels of laminin alpha1 and alpha4 chains were observed in patients with low interacinar fibrosis, but not in those with high interacinar fibrosis. " 03/01/1994 - "We have measured serum laminin, a marker of portal hypertension, in 151 patients with nonmalignant liver diseases, to evaluate its utility in cirrhosis and portal hypertension. " 01/01/2001 - "This study aimed to clarify the role of laminin (a component of the extracellular matrix) in the mechanism of peritoneal fibrosis in continuous ambulatory peritoneal dialysis (CAPD) patients, and the effect of prednisolone on such fibrosis. " 09/01/1987 - "The concentrations of laminin, a high molecular weight non-collagenous glycoprotein of basement membranes, and of the N-terminal propeptide of type III procollagen were determined in the serum of the liver outflow vascular region (hepatic vein) and of a peripheral vein (cubital vein) in patients with chronic liver diseases (fibrosis, cirrhosis, unspecified histology; n = 173), in order to determine their secretion rates from the injured livers. "
5.	Colonic Neoplasms (Colon Cancer) 10/01/2001 - "Overexpression of laminin alpha1 chain in colonic cancer cells induces an increase in tumor growth." 01/01/1994 - "The level and molecular composition of laminin, a major basement membrane glycoprotein formed of three chains (A, B1 and B2) have been analyzed in various human colonic cancer cells (Caco-2 and HT29). " 10/01/2001 - "To further study the biological significance of laminin-1 (composed of alpha1, beta1 and gamma1 chains) in intestinal cell differentiation or tumorigenesis, an alpha1-laminin expression vector was introduced into the HT29 colonic cancer cells, in which laminin alpha1 chain is not expressed. " 01/01/2001 - "Disruption of transforming growth factor beta-regulated laminin receptor function by expression of antisense laminin, a chain RNA in human colon cancer cells."

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)
3.	Peptides (Polypeptides)
4.	Glycoproteins (Glycoprotein)
5.	Laminin (Merosin)
6.	Cadherins (E-Cadherin)
7.	laminin 1
8.	Prednisolone (Predate)
9.	Epidermal Growth Factor (EGF)
10.	Disulfides

Related Therapies and Procedures

1.	Continuous Ambulatory Peritoneal Dialysis (CAPD)
2.	Lasers (Laser)
3.	Glycemic Control