1,1-diethyl-2-hydroxy-2-nitrosohydrazine

RN given in first source; RN refers to ion(1-); do not confuse with DEA-NO cpd

Also Known As:

(C2H5)2N(N(O)NO)-Na+; 1-(N,N-diethylamino)diazen-1-ium-1,2-diolate; DEA-NO; DEA-NONOate; diethylamine NONOate; diethylamine dinitric oxide; diethylamine nitric oxide complex

Networked: 33 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrazines: 379
  - 1,1-diethyl-2-hydroxy-2-nitrosohydrazine: 33

Experts

1.	Miranda, Katrina M: 2 articles (12/2014 - 01/2003)
2.	Wink, David A: 2 articles (12/2014 - 01/2003)
3.	Bagcivan, Ihsan: 2 articles (10/2013 - 05/2007)
4.	Wink, D A: 2 articles (08/2001 - 07/2000)
5.	Castejon, Borja: 1 article (01/2016)
6.	Cuadrado, Irene: 1 article (01/2016)
7.	Martin, Ana M: 1 article (01/2016)
8.	Reventun-Torralba, Paula: 1 article (01/2016)
9.	Saura, Marta: 1 article (01/2016)
10.	Zamorano, Jose Luis: 1 article (01/2016)

Related Diseases

1.	Infarction (Infarctions) 07/01/2000 - "The infarct volume in the vehicle-treated animals was 111 +/- 16.9 mm3; after DEA/NO infusion it was 64.8 +/- 23.4 mm3 (p < 0.01). " 01/01/2003 - "Infarct size and LDH release were also significantly reduced in IPC and AS groups, whereas DEA/NO was less effective in limiting necrosis. " 01/01/2016 - "By contrast, the binding was partially restored when mice were fed with an NO donor (DEA-NO) in the drinking water, showing a significant reduction on infarct size (NOS2KO: 34.6±5 vs NOS2KO+DEA-NO: 20.7±9), in expression of matrix metalloproteinases, and cardiac performance was improved (left ventricular ejection fraction (LVEF). "
2.	Necrosis 01/01/2003 - "Infarct size and LDH release were also significantly reduced in IPC and AS groups, whereas DEA/NO was less effective in limiting necrosis. "
3.	Pre-Eclampsia (Preeclampsia) 10/01/2013 - "Investigation of the role of the NO-cGMP pathway on YC-1 and DEA/NO effects on thoracic aorta smooth muscle responses in a rat preeclampsia model." 10/01/2013 - "The present study was designed to investigate the effects of YC-1, a nitric oxide (NO)-independent soluble guanylate cyclase (sGC) activator, and DEA/NO, a NO donor, on smooth muscle responses in the preeclampsia model with suramin-treated rats and on the levels of cyclic guanosine monophosphate (cGMP) of thoracic aorta rings isolated from term-pregnant rats. "
4.	Neoplasms (Cancer) 08/10/2001 - "The biological mechanisms that control reactivity of nitrogen oxide species formed during autoxidation of nano- to micromolar levels of NO were examined using the synthetic donor NaEt(2)NN(O)NO (DEA/NO), human tumor cells, and 4,5-diaminofluorescein (DAF). " 05/01/1999 - "We investigated whether exposure of tumor cells to NO influences the production, activation, or activity of TGF-beta1.A549 human lung adenocarcinoma cells exposed to the chemical NO donor diethylamine-NONOate showed increased immunoreactivity of cell-associated latent and active TGF-beta1 in a time- and dose-dependent fashion at 24-48 h after treatment. " 02/01/2007 - "These two NO donor molecules allowed proving the electrochemical detection of (i) directly injected exogenous NO phosphate buffer solution into the tumor (decomposed DEA-NONOate) and (ii) biomimetically induced endogeneous release of NO in the tumoral tissue, upon injection of PAPA-NONOate into the tumor. "
5.	Ischemia 10/01/2004 - "Experimental conditions were: (i) baseline control, (ii) NO donor (2-(N,N-diethylamino)-diazenolate 2-oxide, DEA/NO) administration, and (iii) 120 min simulated ischemia (hypoxia). " 01/01/2003 - "Effects were examined after intracoronary perfusion (19 min) of either AS (1 microM), the NO donor diethylamine/NO (DEA/NO, 0.5 microM), vehicle (100 nM NaOH) or buffer, followed by global ischemia (30 min) and reperfusion (30 min or 120 min in a subset of hearts). " 01/01/1999 - "One week later the effects of ischemia-reperfusion on relaxations to NO donors sodium nitroprusside (SNP), diethylamine/NO (DEA/NO), diethylenetriamine/NO (DETA/NO), and spermine/NO (SPER/NO) were studied in rings of middle cerebral artery (MCA) isolated in an organ bath for isometric tension recording. "

Related Drugs and Biologics

1.	Drinking Water
2.	Matrix Metalloproteinases (MMPs)
3.	Nitric Oxide (Nitrogen Monoxide)
4.	Soluble Guanylyl Cyclase
5.	Suramin (Suramin Sodium)
6.	Guanosine Monophosphate (5' Guanylic Acid)
7.	Nitroprusside (Sodium Nitroprusside)
8.	1,1-diethyl-2-hydroxy-2-nitrosohydrazine
9.	1- hydroxy- 2- oxo- 3,3- bis(2- aminoethyl)- 1- triazene
10.	spermine nitric oxide complex

Related Therapies and Procedures

1.	Injections
2.	Aftercare (After-Treatment)