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NPC 17761
bradykinin receptor antagonist
Also Known As:
D-Arg(0)(Hyp(3)-D-HypE(trans-thiophenyl)(7),Oic(8))bradykinin; NPC-17761; Bradykinin, N2-D-arginyl-3-(trans-4-hydroxy-L-proline)-7-(trans-4-(phenylthio)-D-proline)-8-(L-(2alpha,3abeta,7abeta)-octahydro-1H-indole-2-carboxylic acid)-
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Intercellular Signaling Peptides and Proteins: 29768
Kinins: 2029
Bradykinin: 3860
NPC 17761: 2
Nerve Tissue Proteins: 2
Neuropeptides: 6772
Bradykinin: 3860
NPC 17761: 2
Peptides: 82426
Intercellular Signaling Peptides and Proteins: 29768
Kinins: 2029
Bradykinin: 3860
NPC 17761: 2
Neuropeptides: 6772
Bradykinin: 3860
NPC 17761: 2
Oligopeptides: 519
Bradykinin: 3860
NPC 17761: 2
Biological Factors: 2472
Intercellular Signaling Peptides and Proteins: 29768
Kinins: 2029
Bradykinin: 3860
NPC 17761: 2
Inflammation Mediators: 1113
Autacoids: 276
Kinins: 2029
Bradykinin: 3860
NPC 17761: 2
Related Diseases
1.
Sepsis (Septicemia)
01/01/1993 - "
Additive effects of a bradykinin antagonist, NPC 17761, and a leumedin, NPC 15669, on survival in animal models of sepsis.
"
2.
Shock
01/01/1993 - "
The effects of coadministration of NPC 17761 (D-Arg-Arg-Pro-Hyp-Gly-Phe-Ser-D-Hype (transthiophenyl)-Oic-Arg), a potent bradykinin antagonist, and NPC 15669 (N-[9H-(2,7-dimethylfluoren-9-yl-methoxy)carbonyl]-L-leucine), a leukocyte recruitment inhibitor, were examined in rodent models of experimental shock.
"
3.
Pain (Aches)
09/01/1993 - "
4. The new potent and selective B2 receptor antagonists, Hoe 140 (D-Arg[Hyp3,Thi5,D-Tic7,Oic8]-BK), NPC 17731 (D-Arg[Hyp3, trans-4-propoxy-D-proline (transpropyl)7, Oic8]-BK), and NPC 17761 (D-Arg[Hyp3, trans-4-propoxy-D-proline (trans thiophenyl)7, Oic8]-BK) (0.02 to 1.0 nmol/paw), also caused significant inhibitions of both phases of formalin-induced pain.
"
09/01/1993 - "
In contrast, in domethacin (2.7 to 27 micromol kg-1) antagonized only the second phase of formalin-induced pain.6. The B2 receptor antagonists, Hoe 140, NPC 17731, NPC 17761, NPC 349 and NPC 567, all caused a significant inhibition of formalin-induced hindpaw oedema.
"
4.
Leukopenia
01/01/1993 - "
In mice, ED50 doses of NPC 17761 (0.12 mg/kg) and NPC 15669 (4 mg/kg), administered together, increased survival (83%) and inhibited leukopenia (60% at 4 h) in response to a lethal dose of endotoxin.
"
Related Drugs and Biologics
1.
Bradykinin Receptor Antagonists
2.
Proline (L-Proline)
3.
Leucine (L-Leucine)
4.
Formaldehyde (Formol)
5.
Endotoxins
6.
hydroxyprolyl-glycine
7.
arginylarginine (Arg-Arg)
8.
NPC 17731
9.
N- (9H- (2,7- dimethylfluoren- 9- ylmethoxy)carbonyl)leucine
10.
icatibant