|1.||Paterson, Ian: 2 articles (07/2005 - 02/2003)|
|2.||Bach, Jordi: 2 articles (07/2005 - 02/2003)|
|3.||Coster, Mark J: 2 articles (07/2005 - 02/2003)|
|4.||Atasoylu, Onur: 1 article (09/2011)|
|5.||Risatti, Christina A: 1 article (09/2011)|
|6.||Sperry, Jeffrey B: 1 article (09/2011)|
|7.||Huang, Kuan-Chun: 1 article (09/2011)|
|8.||Nomoto, Kenichi: 1 article (09/2011)|
|9.||Xu, Qunli: 1 article (09/2011)|
|10.||Liu, Junke: 1 article (09/2011)|
09/01/2008 - "Our data show that spongistatin 1 represents a promising novel therapeutic agent for the treatment of leukemic tumor cells especially in the clinically highly relevant situation of chemoresistance due to overexpression of XIAP."
09/01/2011 - "The marine natural product (+)-spongistatin 1 is an extremely potent growth inhibitory agent having activity against a wide variety of cancer cell lines, while exhibiting low cytotoxicity against quiescent human fibroblasts. "
09/01/2010 - "Exposure to spongistatin 1 leads to phosphorylation, and thus inactivation of the antiapoptotic protein Bcl-2 in pancreatic tumor cells. "
09/01/2010 - "Spongistatin 1 significantly reduced tumor growth, which correlates with a strong apoptosis induction (DNA-fragmentation) and long-term effects on clonogenic survival of pancreatic tumor cells (L3.6pl) in vitro. "
09/01/2008 - "In apoptosis-resistant leukemic tumor cells overexpressing XIAP, spongistatin 1 effectively causes cell death and potentiates cell death induction by other apoptosis-promoting factors that might be caused by spongistatin 1-mediated degradation of XIAP. "
|2.||Dehydration (Water Stress)
07/07/2005 - "Two structural analogues were also prepared and evaluated as growth inhibitory agents against a range of human tumour cell lines, including Taxol-resistant strains, alongside altohyrtin A and paclitaxel (Taxol), revealing that dehydration in the E-ring is tolerated and results in enhanced cytotoxicity (at the low picomolar level), whereas the presence of the full C44-C51 side-chain appears to be crucial for biological activity."
02/21/2003 - "Simplified analogues of the potent antimitotic marine macrolide spongistatin 1/altohyrtin A were synthesised and evaluated as growth inhibitory agents against a range of human tumour cell lines, including Taxol-resistant strains, revealing that E-ring dehydration leads to enhanced cytotoxicity at the low picomolar level while truncation of the side-chain at C46 results in a drastic decrease in activity."
|3.||Prostatic Neoplasms (Prostate Cancer)
|4.||Pancreatic Neoplasms (Pancreatic Cancer)
|5.||Neoplasm Metastasis (Metastasis)
09/01/2010 - "Taken together, spongistatin 1 not only proved to be a potent experimental drug but also served as a chemical tool to examine the role of the antiapoptotic protein Bcl-2 in pancreas carcinoma, thereby supporting the hypothesis of a link between apoptosis signaling and metastasis."
09/01/2010 - "The marine compound spongistatin 1 targets pancreatic tumor progression and metastasis."
|3.||Amphotericin B (Amphotericin)
|1.||Heterologous Transplantation (Xenotransplantation)