brucine

was heading 1991-94 (see under STRYCHNINE 1975-90); DIMETHOXYSTRYCHNINE was see BRUCINE 1975-94; use STRYCHNINE to search BRUCINE 1975-94; very toxic alkaloid from Nux vomica similar to strychnine; used as reagent in analytical chemistry; was MH 1991-94

Also Known As:

Networked: 71 relevant articles (4 outcomes, 29 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chen, Jun: 5 articles (11/2014 - 04/2011)
2.	Cai, Bao-Chang: 5 articles (07/2013 - 10/2003)
3.	Li, Ping: 4 articles (01/2019 - 08/2012)
4.	Zhang, Mei: 4 articles (01/2019 - 08/2012)
5.	Yin, Wu: 4 articles (10/2013 - 10/2003)
6.	Zhang, Yanmin: 3 articles (07/2018 - 08/2013)
7.	Shen, Xu-Liang: 3 articles (06/2014 - 04/2011)
8.	Zhang, Guo-Xiang: 3 articles (06/2014 - 04/2011)
9.	Deng, Xukun: 3 articles (10/2013 - 05/2006)
10.	Elsewedy, Heba S: 2 articles (06/2021 - 12/2020)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2013 - "To study the possible anti-cancer mechanisms on LoVo cells, effects of Brucine on cell viability, cell cycle and apoptosis were investigated. " 05/10/2013 - "In this study, we investigated the mechanism of brucine in tumor angiogenesis. " 01/01/2012 - "Recent studies have showed that brucine has a good anti-tumor effect, but high toxicity, poor water solubility, short half-life, narrow therapeutic window, and a toxic dose that is close to the therapeutic dose, which all limit its clinical application. " 01/01/2021 - "Moreover, U87 tumors were suppressed by brucine in a tumor xenograft nude mouse model. " 01/01/2020 - "Therefore, Brucine may be used as an ICD inducer and improve its application in cancer treatment with minimized toxicity."
2.	Pain (Aches) 10/01/2009 - "To reduce the toxicity and enhance the therapeutic efficacy of brucine, a traditional Chinese medicine for relieving arthritic and traumatic pain, in this study, a novel brucine-loaded liposomal hydrogel (BLH) formulation, suitable for topical application, was developed. " 10/01/2003 - "These results suggest that central and peripheral mechanism are involved in the pain modulation and anti-inflammation effects of brucine and brucine N-oxide, biochemical mechanisms of brucine and brucine N-oxide are different even though they are similar in chemical structure." 10/01/2003 - "(Loganiaceae) as well as analgesic and anti-inflammatory activities of brucine and brucine N-oxide extracted from this medicinal plant, various pain and inflammatory models were employed in the present study to investigate their pharmacological profiles. " 04/06/2019 - "Brucine, the second abundant alkaloid constituent of nux vomica, shows excellent clinical therapeutic effect, especially in relieving pain, but mechanism of brucine in relieving pain is still unclear. " 04/03/2017 - "Moreover, the brucine gel eased the pain of paw formalin injection in the formalin test, which demonstrated its analgesic effects. "
3.	Cholangiocarcinoma 01/01/2023 - "Conclusions Brucine can significantly inhibit the progression of cholangiocarcinoma in vitro and in vivo, and the mechanism may be related to the inhibition of COX-2 expression." 01/01/2023 - "Aims The aim of this study was to investigate the anti-tumor efficacy of brucine on intrahepatic cholangiocarcinoma (ICC). "
4.	Glioblastoma (Glioblastoma Multiforme) 01/01/2021 - "Therefore, brucine is potentially effective for treating glioblastomas." 01/01/2021 - "Brucine inhibits proliferation of glioblastoma cells by targeting the G-quadruplexes in the c-Myb promoter." 01/01/2014 - "Inhibition of Glioblastoma Cell Growth In Vitro and In Vivo by Brucine, a Component of Chinese Medicine."
5.	Edema (Dropsy) 01/06/2012 - "Brucine showed to be effective in acetic acid-induced writhing and xylene-induced ear edema test. " 10/01/2003 - "Brucine N-oxide showed stronger inhibitory effect than brucine in carrageenan-induced rat paw edema, both of them significantly inhibited the release of prostaglandin E2 in inflammatory tissue, reduced acetic acid-induced vascular permeability and the content of 6-keto-PGF1a in Freund's complete adjuvant (FCA) induced arthritis rat's blood plasma. "

Related Drugs and Biologics

1.	Hydrogels
2.	Acetic Acid (Vinegar)
3.	Xylenes (Xylene)
4.	Strychnine
5.	Analgesics (Analgesic Drugs)
6.	Alkaline Phosphatase
7.	Bortezomib (Velcade)
8.	Alkaloids
9.	brucine N-oxide
10.	Enzymes

Related Therapies and Procedures

1.	Chinese Traditional Medicine (Traditional Chinese Medicine)
2.	Therapeutics
3.	Traditional Medicine (Folk Remedies)
4.	Intravenous Administration
5.	Photochemotherapy (Photodynamic Therapy)