|1.||Chen, Jun: 5 articles (11/2014 - 04/2011)|
|2.||Cai, Bao-Chang: 5 articles (07/2013 - 10/2003)|
|3.||Yin, Wu: 4 articles (10/2013 - 10/2003)|
|4.||Shen, Xu-Liang: 3 articles (06/2014 - 04/2011)|
|5.||Zhang, Guo-Xiang: 3 articles (06/2014 - 04/2011)|
|6.||Deng, Xukun: 3 articles (10/2013 - 05/2006)|
|7.||Gu, Wei: 2 articles (11/2014 - 04/2013)|
|8.||Zhang, Mei: 2 articles (06/2014 - 08/2012)|
|9.||Li, Ping: 2 articles (06/2014 - 08/2012)|
|10.||Wei, Wu: 2 articles (06/2014 - 04/2011)|
10/01/2003 - "(Loganiaceae) as well as analgesic and anti-inflammatory activities of brucine and brucine N-oxide extracted from this medicinal plant, various pain and inflammatory models were employed in the present study to investigate their pharmacological profiles. "
10/01/2009 - "To reduce the toxicity and enhance the therapeutic efficacy of brucine, a traditional Chinese medicine for relieving arthritic and traumatic pain, in this study, a novel brucine-loaded liposomal hydrogel (BLH) formulation, suitable for topical application, was developed. "
03/01/2012 - "Its major bioactive constituents are strychnine and brucine, which are frequently used in traditional herbal medicines for treatment of nervous diseases, vomiting and traumatic pain. "
10/01/2003 - "These results suggest that central and peripheral mechanism are involved in the pain modulation and anti-inflammation effects of brucine and brucine N-oxide, biochemical mechanisms of brucine and brucine N-oxide are different even though they are similar in chemical structure."
01/06/2012 - "Brucine showed to be effective in acetic acid-induced writhing and xylene-induced ear edema test. "
10/01/2003 - "Brucine N-oxide showed stronger inhibitory effect than brucine in carrageenan-induced rat paw edema, both of them significantly inhibited the release of prostaglandin E2 in inflammatory tissue, reduced acetic acid-induced vascular permeability and the content of 6-keto-PGF1a in Freund's complete adjuvant (FCA) induced arthritis rat's blood plasma. "
08/01/2013 - "To study the possible anti-cancer mechanisms on LoVo cells, effects of Brucine on cell viability, cell cycle and apoptosis were investigated. "
05/10/2013 - "Taken together, our study suggests that brucine potently suppresses angiogenesis by targeting VEGFR2 activation and may be a viable drug candidate in anti-angiogenesis and anti-cancer therapies."
05/10/2013 - "In this study, we investigated the mechanism of brucine in tumor angiogenesis. "
01/01/2012 - "Recent studies have showed that brucine has a good anti-tumor effect, but high toxicity, poor water solubility, short half-life, narrow therapeutic window, and a toxic dose that is close to the therapeutic dose, which all limit its clinical application. "
11/20/2014 - "Treating the tumor-bearing mice with LTSL, HTSL and NTSL led to significantly increased brucine uptake in the heated tumor site compared to the brucine solution group by 2.30, 3.80 and 2.26-fold, respectively. "
02/01/2013 - "The aim of this study was to investigate the mechanism of the apoptotic effect of brucine on human multiple myeloma (MM) cells. "
02/01/2013 - "Brucine induces the apoptosis of U266 multiple myeloma cells by phosphorylation of c-Jun."
08/01/2012 - "Brucine exerts effects on bone metabolism in multiple myeloma through the regulation of osteoclasts by osteoblasts."
08/01/2012 - "Effects of brucine on bone metabolism in multiple myeloma."
04/01/2011 - "[Effect of brucine on metabolism of osteoblasts and osteoclasts in multiple myeloma]."
|5.||Neoplasm Metastasis (Metastasis)
10/24/2013 - "Our current study demonstrated the capacity of brucine in suppressing HCC cell migration in vitro and lung metastasis in vivo. "
10/24/2013 - "The inhibition of the HIF-1 pathway is implicated in the anti-metastasis activity of brucine."
10/24/2013 - "There has thus far been little research into brucine as a source of anti-metastasis activity against HCC. "
10/24/2013 - "Experiments in vivo showed that an intraperitoneal injection of 5 and 15 mg/kg of brucine resulted in dose-dependent decreases in the lung metastasis of H22 ascitic hepatoma cells. "
08/01/2012 - "Brucine could inhibit the growth of breast cancer to bone metastases, possibly by inhibiting tumor angiogenesis."
|2.||Acetic Acid (Vinegar)
|8.||Cyclooxygenase 2 (Cyclooxygenase-2)
|9.||Messenger RNA (mRNA)
|1.||Chinese Traditional Medicine (Traditional Chinese Medicine)
|2.||Heterologous Transplantation (Xenotransplantation)
|3.||Photochemotherapy (Photodynamic Therapy)
|4.||Traditional Medicine (Folk Remedies)