aggrecanase

cleaves aggrecan from articular cartilage predominantly between Glu-373 and Ala-374; activity found in bovine articular cartilage, bovine growth plate and chondrocyte monolayer cultures

Also Known As:

Networked: 108 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lohmander, L S: 5 articles (05/2012 - 02/2006)
2.	Larsson, S: 4 articles (05/2012 - 02/2006)
3.	Struglics, A: 4 articles (05/2012 - 02/2006)
4.	Lohmander, L Stefan: 3 articles (12/2012 - 01/2009)
5.	Struglics, André: 3 articles (12/2012 - 01/2009)
6.	Arner, Elizabeth C: 3 articles (01/2008 - 02/2002)
7.	Tortorella, Micky D: 3 articles (01/2008 - 02/2002)
8.	Caterson, B: 3 articles (01/2008 - 08/2000)
9.	Sandy, J D: 3 articles (07/2007 - 02/2000)
10.	Pratta, M A: 3 articles (07/2006 - 06/2001)

Related Diseases

1.	Osteoarthritis 01/01/2021 - "Dysregulated aggrecanase activity of ADAMTS-5 has been directly linked to the etiology of osteoarthritis (OA). " 09/29/2016 - "In conclusion, inhibition of SDF-1α/CXCR4 signaling axis was able to inhibit aggrecanase expression and lessen cartilage degeneration in post-traumatic osteoarthritis rats." 09/29/2016 - "CXCL12/CXCR4 Axis Regulates Aggrecanase Activation and Cartilage Degradation in a Post-Traumatic Osteoarthritis Rat Model." 01/01/2016 - "These data demonstrate that the antibody is specific to ADAMTS4 and ADAMTS5 and inhibits their aggrecanase activity at molecular and cellular levels, and suggest that this antibody may be useful for treatment of pathological conditions such as osteoarthritis. " 04/01/2013 - "For this reason, considerable effort has been put on the discovery and development of aggrecanase inhibitors able to slow down or halt the progression of osteoarthritis. "
2.	Chondrosarcoma 11/01/2000 - "Catabolism by aggrecanase activities induced in rat chondrosarcoma cells, porcine chondrocytes, and by human recombinant ADAMTS4 showed a gradually decreasing catabolism of progressively shortened, N-terminal deletion mutants of the substrate rAgg1mut. " 10/01/2000 - "Kinetic analysis of the products present in rat chondrosarcoma cell cultures treated with interleukin-1b showed that the first aggrecanase-mediated cleavages occurred at the four sites within the CS attachment region to generate two stable intermediates, Val(1)-Glu(1459) and Val(1)-Glu(1274). " 08/08/1997 - "(iii) A considerable time period was required to synthesize and/or activate aggrecanase, with considerable differences in that found in rat chondrosarcoma versus bovine chondrocyte culture systems. " 08/08/1997 - "Using this recombinant substrate we developed a novel agarose cell culture system containing either rat chondrosarcoma or bovine chondrocytes that could be used in studies of the biochemical characterization of aggrecanase activities. " 07/01/1998 - "Studies in vitro with retinoic acid-stimulated rat chondrosarcoma cells indicated that the rAgg1mut substrate was cleaved at the 'aggrecanase' site equivalent to Glu373-Ala374 (human aggrecan sequence enumeration) in its interglobular domain sequence segment. "
3.	Joint Diseases (Joint Disease) 12/01/2012 - "These markers can be used to monitor aggrecanase activity in human joint disease. " 01/01/2009 - "The newly developed ARGS fragment assay can be used to monitor aggrecanase activity in human joint disease and experimental models." 09/01/2004 - "Coincident with aggrecanolysis, aggrecanase activities in articular cartilage may actuate the release of HA and associated hyaladherins, thereby further compromising the integrity of the cartilage matrix during degenerative joint diseases such as osteoarthritis." 09/01/1993 - "Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis." 01/01/2002 - "CSA can inhibit IL-1-induced aggrecanase-mediated proteoglycan catabolism in articular cartilage explants maintained in culture for 4 days, thus demonstrating molecular mechanisms whereby CSA may be an effective therapy for degenerative joint disease."
4.	Neoplasms (Cancer) 08/01/2020 - "ADAMTS 5, which causes the degradation of the ECM with Aggrecanase activity, was found to be significantly higher in patients diagnosed with cancer and ADAMTS 8 with anti-angiogenesis activity was significantly lower in patients diagnosed with endometrial cancer.What" 05/01/2005 - "The aggrecanase inhibitory effect of LMWH might contribute to blocking inflammation and tumor invasion by inhibiting aggrecanase activity and maintaining an intact extracellular matrix barrier." 04/01/2013 - "Overall, the results of the present study show that ADAMTS-5/aggrecanase-2 is the main aggrecanase present in laryngeal carcinoma suggesting a critical role for the enzyme in aggrecan degradation and laryngeal tissue destruction during tumor progression."
5.	Arthralgia (Joint Pain) 08/01/2018 - "Our study aimed to identify and develop a novel biomarker by measuring an aggrecanase-mediated type III collagen neoepitope, and correlate levels of this biomarker with OA joint pain. "

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	Aggrecans (Aggrecan)
3.	Enzymes
4.	Collagen
5.	Collagen Type III (Type III Collagen)
6.	Glycosaminoglycans
7.	Tretinoin (Retinoic Acid)
8.	Sepharose (Agarose)
9.	ADAMTS5 Protein
10.	Matrix Metalloproteinases (MMPs)

Related Therapies and Procedures

1.	Therapeutics
2.	Intra-Articular Injections
3.	Meniscectomy