|1.||Lin, L: 1 article (11/2011)|
|2.||Joa Qin, C: 1 article (11/2011)|
|3.||Peng, H: 1 article (11/2011)|
|4.||Mao Cai, W: 1 article (11/2011)|
|5.||Ying, R: 1 article (11/2011)|
|6.||Chi Miao, L: 1 article (11/2011)|
|7.||Gu Yang, T: 1 article (11/2011)|
|8.||Wen Tao, Z: 1 article (11/2011)|
|9.||Wang, Liang-Chun: 1 article (12/2007)|
|10.||Chen, Jia-Qin: 1 article (12/2007)|
11/01/2011 - "Therefore, the present results show that the epidural administration of HWTX-I is effective in antinociception in the rat model of rheumatoid arthritis, which may act through its inhibition on certain inflammatory pathways."
11/01/2011 - "In the present study we investigated the possible molecular mechanism of the antinociceptive efficacy of HWTX-I, a spider peptide toxin blocking Ca2+ channels, on the rat rheumatoid arthritis model. "
11/01/2011 - "The antinociceptive efficacy of HWTX-I epidurally administered in rheumatoid arthritis rats."
11/01/2011 - "HWTX-I can also decrease the mRNA expression level of related factors of TNF-α, interleukin 1β (IL-1β) and interleukin 6(IL-6) in inflammatory pathways in rheumatoid arthritis. "
11/01/2011 - "Our study demonstrates that HWTX-I can relieve pain in the inflammatory joints and eliminate arthrocele to some degree. "
06/01/2005 - "Based on its biological activity, HWTX-I could be developed as a pain-killer for clinical purpose. "
01/01/2005 - "[Analgesic effect of huwentoxin-I, a new N-type voltage-sensitive calcium channel blocker, on acute visceral pain in rats]."
01/01/2005 - "To study the antinociceptive effect of intrathecally administered huwentoxin-I (HWTX-I or HWAP-I) on visceral pain in rats with acute colon inflammation. "
|5.||Brain Ischemia (Cerebral Ischemia)
12/15/2007 - "Effect of Huwentoxin-I on the Fas and TNF apoptosis pathway in the hippocampus of rat with global cerebral ischemia."
12/15/2007 - "In the present studies, we investigated the molecular mechanism for the neuro-protective effect of Huwentoxin-I (HWTX-I), a spider toxin selectively blocking N-type voltage-dependent Ca((2+)) channel, on rat models with global cerebral ischemia-reperfusion injury. "
|2.||Calcium Channels (Calcium Channel)
|3.||Messenger RNA (mRNA)