S 2720

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2 relevant articles (0 outcomes, 0 trials/studies) found for this Bio-Agent

Description: potent inhibitor of both human immunodeficiency virus type 1 reverse transcriptase activity & HIV-1 replication in tissue culture; structure given in first source

Also Known As:

6-chloro-3,3-dimethyl-4-(isopropenyloxycarbonyl)-3,4-dihydroquinoxalin-2(1H)-thione; S-2720; 1(2H)-Quinoxalinecarboxylic acid, 7-chloro-3,4-dihydro-2,2-dimethyl-3-thioxo-, 1-methylethenyl ester

Bio-Agent Context: Research Results

Heterocyclic Compounds: 23

2-Ring Heterocyclic Compounds

Quinoxalines: 8

S 2720: 2

Related Diseases

Infection

08/01/1993 - "As no toxic effects were observed with S-2720 in mice, these quinoxaline derivatives deserve further evaluation to prove their potency as possible therapeutic agents for HIV-1 infection."
12/01/1994 - "Moreover, quinoxaline S-2720 totally prevented HIV-1 infection and emergence of drug-resistant mutant virus strains in CEM cell cultures at concentrations (i.e., 0.35 microM) that are 10- to 25-fold lower than those required for BHAP U-88204 and nevirapine to knock out the virus"
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1 Diseases and 2 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	Nevirapine (Viramune)
2.	U 88204
2 Drugs and Important Bio-Agents and 1 more articles analyzed in the Research Interface, order at left...

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