pyrrolidine-2,4-dicarboxylic acid

a glutamate uptake inhibitor

Also Known As:

1-pyrrolidine-2,4-dicarboxylic acid; 1-trans-pyrrolidine-2,4-dicarboxylic acid; 2,4-pyrrolidine dicarboxylate; L-pyrrolidine-2,4-dicarboxylic acid; L-trans-2,4-pyrrolidine dicarboxylate; L-trans-pyrrolidine-2,4-dicarboxylic acid; PDC-2,4; pyrrolidine-2,4-dicarboxylate; pyrrolidine-2,4-dicarboxylic acid, (2R-cis)-isomer; pyrrolidine-2,4-dicarboxylic acid, (2R-trans)-isomer; pyrrolidine-2,4-dicarboxylic acid, (2S-cis)-isomer; pyrrolidine-2,4-dicarboxylic acid, (2S-trans)-isomer; 2,4-Pyrrolidinedicarboxylic acid

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Hirsch, E C: 1 article (01/2016)
2.	Lavaur, J: 1 article (01/2016)
3.	Le Nogue, D: 1 article (01/2016)
4.	Lemaire, M: 1 article (01/2016)
5.	Michel, P P: 1 article (01/2016)
6.	Pype, J: 1 article (01/2016)
7.	Anand, Amit: 1 article (03/2007)
8.	Gaskins, Denise: 1 article (03/2007)
9.	Lee, Younglim: 1 article (03/2007)
10.	Shekhar, Anantha: 1 article (03/2007)

Related Diseases

1.	Hypoxia (Hypoxemia) 07/15/1999 - "Inhibition of Na(+)-dependent glutamate transport with dihydrokainate or l-trans-pyrrolidine-2,4-dicarboxylic acid (1 mm each) protected against anoxia (65-75 vs 25%) and trauma (70 vs 35%). " 10/01/2001 - "Cell cultures were prepared from adult pig retinas and maintained under different experimental conditions of increasing hypoglycemia, environmental hypoxia (delayed postmortem period or atmospheric PO2 <2%), or chemical hypoxia (potassium cyanide), or in the presence of glutamate transporter blockers L-trans-pyrrolidine-2,4-dicarboxylic acid (tPDC) and L(-)-threo-3-hydroxyaspartic acid (THA), or the glutamine synthetase inhibitor methionine sulfoximine (MS). "
2.	Mood Disorders (Mood Disorder) 03/01/2007 - "We demonstrate that chronic blockade of glutamate uptake by a glial/neuronal transporter antagonist L-trans-pyrrolidine-2,4-dicarboxylic acid (PDC) within the amygdala, a key area implicated in mood regulation, results in dose-dependent reduction in social exploratory behavior and disrupts circadian activity patterns consistent with symptoms of mood disorders. "
3.	Wounds and Injuries (Trauma) 07/15/1999 - "Inhibition of Na(+)-dependent glutamate transport with dihydrokainate or l-trans-pyrrolidine-2,4-dicarboxylic acid (1 mm each) protected against anoxia (65-75 vs 25%) and trauma (70 vs 35%). "
4.	Neoplasms (Cancer) 01/01/2023 - "Results: In vitro cell uptake assays showed that the tracers accumulated in cancer cells in a time-dependent manner and that the uptake of [18F]FASu was blocked by the system [Formula: see text] inhibitor sulfasalazine and rose bengal, but not by system L inhibitor 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid, system [Formula: see text] inhibitor L-trans-pyrrolidine-2,4-dicarboxylic acid, or l-serine, which is a substrate for transporter systems A, ACS, B0, and B0,+ Conversely, [18F]FSPG uptake decreased significantly in the presence of an excess of L-trans-pyrrolidine-2,4-dicarboxylic acid in 2 of 3 tested cell lines, indicating some reliance on system [Formula: see text] in these cells. "
5.	Hypoglycemia (Reactive Hypoglycemia) 10/01/2001 - "Cell cultures were prepared from adult pig retinas and maintained under different experimental conditions of increasing hypoglycemia, environmental hypoxia (delayed postmortem period or atmospheric PO2 <2%), or chemical hypoxia (potassium cyanide), or in the presence of glutamate transporter blockers L-trans-pyrrolidine-2,4-dicarboxylic acid (tPDC) and L(-)-threo-3-hydroxyaspartic acid (THA), or the glutamine synthetase inhibitor methionine sulfoximine (MS). "

Related Drugs and Biologics

1.	Glutamic Acid (Glutamate)
2.	Acids
3.	Amino Acid Transport System X-AG (Glutamate Transporter)
4.	Solutions
5.	Serine (L-Serine)
6.	Sulfasalazine (Azulfidine)
7.	Rose Bengal
8.	Potassium Cyanide
9.	Methionine Sulfoximine
10.	Glutamate-Ammonia Ligase (Glutamine Synthetase)