|1.||Sloan, Edward P: 8 articles (02/2015 - 05/2002)|
|2.||Pape, A: 5 articles (11/2004 - 02/2000)|
|3.||Koenigsberg, Max: 4 articles (02/2015 - 05/2002)|
|4.||Kleen, M: 4 articles (11/2004 - 02/2000)|
|5.||Meisner, F: 4 articles (11/2004 - 02/2000)|
|6.||Kemming, G: 4 articles (11/2004 - 02/2000)|
|7.||Habler, O: 4 articles (11/2004 - 02/2000)|
|8.||Clark, James M: 3 articles (02/2015 - 08/2012)|
|9.||DCLHb Traumatic Hemorrhagic Shock Study Group: 3 articles (05/2010 - 05/2002)|
|10.||Fabian, Timothy C: 3 articles (05/2004 - 03/2002)|
02/01/2000 - "Shock-induced disturbances of the distribution of RMP were improved by administration of DCLHb but not by HSA."
03/01/2005 - "Although DCLHb, HbG, and HAR induce HO-1 in the absence of an unspecific stress response, only HAR pretreatment protects against shock-induced organ failure. "
03/01/2005 - "High doses of DCLHb pretreatment increased mortality (2 hrs of shock, 80%; p < .05 vs. vehicle or HAR). "
03/01/2005 - "Pretreatment with DCLHb or HbG shortened the onset of decompensation in shock (DCLHb, 40 +/- 11 mins; HbG, 36 +/- 4 mins) compared with vehicle (68 +/- 4 mins, p < .05) and HAR pretreatment (81 +/- 7 mins, p < .05). "
05/01/2003 - "Causes and number of deaths were as follows: rHb, zero of six; BL-transfusion reaction, one of six; LR-irreversible shock, four of six; and DCLHb-ventricular failure, six of six. "
11/01/2014 - "We used data from two parallel DCLHb traumatic hemorrhagic shock efficacy trials, one in U.S. "
02/01/2010 - "The lack of consistent diaspirin cross-linked hemoglobin infusion blood pressure effects in the US and EU traumatic hemorrhagic shock clinical trials."
03/01/2005 - "The aim of the study was to assess the role of pretreatment with DCLHb, HbG, or HAR on HO-1 expression and organ injury after hemorrhagic shock. "
11/01/2002 - "Post hoc mortality analysis on the efficacy trial of diaspirin cross-linked hemoglobin in the treatment of severe traumatic hemorrhagic shock."
05/01/2002 - "Patients were enrolled in this DCLHb hemorrhagic shock study using 28-day mortality as the primary endpoint. "
|3.||Brain Ischemia (Cerebral Ischemia)
01/01/1994 - "The results of this study support the hypothesis that hemodilution with DCLHb decreases cerebral ischemia in a dose-dependent manner, and in terms of brain ischemia is a more proficient hemodiluting fluid than albumin."
11/01/1992 - "The results of this study support a hypothesis that hemodilution with DCLHb decreases the extent of focal cerebral ischemia."
05/01/1999 - "The data do not support the notion that intravascular DCLHb has an adverse effect on cerebral ischemia after subarachnoid hemorrhage."
08/01/1996 - "These data indicate that in this model of cerebral ischemia, DCLHb decreases ischemic brain injury more effectively than albumin, and that a hyperoncotic preparation of DCLHb is preferable."
01/01/1997 - "One mechanism whereby DCLHb may ameliorate cerebral ischemia is by binding nitric oxide (NO), which has been implicated as neurotoxic. "
12/01/2003 - "After hemorrhage, a low volume of DCLHb restored both cardiac and intestinal microPO2. "
06/01/2000 - "Subsequently, the volume of plasma lost during hemorrhage was replaced by either a balanced electrolyte solution containing 10 g/dL DCLHb (DCLHb group; n = 10) or an 8 g/dL human albumin solution (HSA) oncotically matched to DCLHb (HSA group; n = 10). "
08/01/1997 - "It is concluded that the ET mechanism is more important in the beneficial effect of DCLHb than the NO mechanism in hemorrhage."
08/01/1997 - "Role of ET and NO in resuscitative effect of diaspirin cross-linked hemoglobin after hemorrhage in rat."
09/01/1996 - "In this swine model of hemorrhage, even small doses of DCLHb exerted measurable beneficial effects on blood pressure and perfusion."
|5.||Craniocerebral Trauma (Head Injury)
05/01/1998 - "Using a rodent model of head injury combined with ischaemia, we studied the effects of DCLHb on cerebral blood flow (CBF) and intracranial pressure (ICP). "
11/01/1996 - "Key Words: Diaspirin cross-linked hemoglobin, Head injury, Shock, Cerebral perfusion pressure."
11/01/1996 - "These data suggest that DCLHb is beneficial in the early resuscitation of head injury and shock and that further investigation is warranted. "
01/01/1997 - "Effect of hemodilution with diaspirin cross-linked hemoglobin on intracranial pressure, cerebral perfusion pressure, and fluid requirements after head injury and shock."
11/01/1996 - "Diaspirin cross-linked hemoglobin resuscitation improves cerebral perfusion after head injury and shock."
|5.||3- (2- carboxypiperazin- 4- yl)propyl- 1- phosphonic acid (CPP)
|6.||Blood Substitutes (Artificial Blood)
|10.||Interleukin-6 (Interleukin 6)
|3.||Cardiopulmonary Resuscitation (CPR)