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geranylgeranyltransferase type-I (protein geranylgeranyltransferase)

involved in protein isoprenylation; transfers geranylgeranyl group to Cys fourth from the C-terminal of GTP-binding proteins; see also Rab, ras, and rhoA p21 geranylgeranyl- transferases and component A, Rab geranylgeranyltransferase; RefSeq NM_172627 (mouse); NM_031082 (rat); NM_005023 (human)
Also Known As:
protein geranylgeranyltransferase; CAAX geranylgeranyl transferase; GGTase I; GGTase-I; PGGT1B protein, human; Pggt1b protein, mouse; Pggt1b protein, rat; geranylgeranyl-protein transferase type 1; geranylgeranyltransferase I; geranylgeranyltransferase ras protein; protein GGTase; protein geranylgeranyltransferase type I, beta subunit, human; protein geranylgeranyltransferase type I, beta subunit, mouse; protein geranylgeranyltransferase type I, beta subunit, rat; ras protein GG transferase; ras protein geranylgeranyltransferase
Networked: 70 relevant articles (2 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Bergo, Martin O: 8 articles (01/2020 - 05/2007)
2. Karlsson, Christin: 5 articles (01/2019 - 05/2007)
3. Casey, Patrick J: 5 articles (01/2016 - 10/2004)
4. Young, Stephen G: 5 articles (02/2013 - 05/2007)
5. Akula, Murali K: 4 articles (01/2022 - 02/2013)
6. Andersson, Karin M E: 3 articles (01/2022 - 05/2007)
7. Brisslert, Mikael: 3 articles (01/2022 - 02/2011)
8. Ibrahim, Mohamed X: 3 articles (01/2019 - 04/2010)
9. Khan, Omar M: 3 articles (01/2019 - 02/2011)
10. Kwon, Ohyun: 3 articles (01/2015 - 05/2009)

Related Diseases

1. Neoplasms (Cancer)
2. Lung Neoplasms (Lung Cancer)
3. Atherosclerosis
4. Breast Neoplasms (Breast Cancer)
5. Glioma (Gliomas)

Related Drugs and Biologics

1. geranylgeranyltransferase type-I (protein geranylgeranyltransferase)
2. Farnesyltranstransferase (Farnesyltransferase)
3. Enzymes
4. Proteins (Proteins, Gene)
5. Transferases
6. Peptidomimetics
7. Rab geranylgeranyl transferase beta-subunit
8. 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA)
9. Green Fluorescent Proteins
10. GTP Phosphohydrolases (GTPases)

Related Therapies and Procedures

1. Therapeutics
2. Radiotherapy
3. Drug Therapy (Chemotherapy)
4. Aftercare (After-Treatment)