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geranylgeranyltransferase type-I (protein geranylgeranyltransferase)

involved in protein isoprenylation; transfers geranylgeranyl group to Cys fourth from the C-terminal of GTP-binding proteins; see also Rab, ras, and rhoA p21 geranylgeranyl- transferases and component A, Rab geranylgeranyltransferase; RefSeq NM_172627 (mouse); NM_031082 (rat); NM_005023 (human)
Also Known As:
protein geranylgeranyltransferase; CAAX geranylgeranyl transferase; GGTase I; GGTase-I; PGGT1B protein, human; Pggt1b protein, mouse; Pggt1b protein, rat; geranylgeranyl-protein transferase type 1; geranylgeranyltransferase I; geranylgeranyltransferase ras protein; protein GGTase; protein geranylgeranyltransferase type I, beta subunit, human; protein geranylgeranyltransferase type I, beta subunit, mouse; protein geranylgeranyltransferase type I, beta subunit, rat; ras protein GG transferase; ras protein geranylgeranyltransferase
Networked: 50 relevant articles (2 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Bergo, Martin O: 6 articles (02/2013 - 05/2007)
2. Young, Stephen G: 5 articles (02/2013 - 05/2007)
3. Karlsson, Christin: 4 articles (02/2013 - 05/2007)
4. Kwon, Ohyun: 3 articles (01/2015 - 05/2009)
5. Lu, Jie: 3 articles (01/2015 - 05/2009)
6. Tamanoi, Fuyuhiko: 3 articles (01/2015 - 05/2009)
7. Liu, Meng: 3 articles (02/2011 - 05/2007)
8. Sjogren, Anna-Karin M: 3 articles (02/2011 - 05/2007)
9. Casey, Patrick J: 3 articles (07/2009 - 05/2007)
10. Sebti, Saïd M: 3 articles (04/2009 - 12/2003)

Related Diseases

1. Neoplasms (Cancer)
2. Lung Neoplasms (Lung Cancer)
3. Breast Neoplasms (Breast Cancer)
4. Glioma (Gliomas)
5. Atherosclerosis

Related Drugs and Biologics

1. geranylgeranyltransferase type-I (protein geranylgeranyltransferase)
2. Farnesyltranstransferase (Farnesyltransferase)
3. GTP Phosphohydrolases (GTPases)
4. LDL Receptors (LDL Receptor)
5. Gliotoxin
6. L 778,123
7. GGTI 298
8. Insulin (Novolin)
9. Proteins (Proteins, Gene)
10. FTI 277

Related Therapies and Procedures

1. Radiotherapy
2. Heterologous Transplantation (Xenotransplantation)
3. Therapeutics
4. Aftercare (After-Treatment)