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pentolame
17-beta-amino-estrogen with anticoagulant & estrogenic effects; structure given in first source
Also Known As:
17 beta-(5'-hydroxy-1'-pentylamino)-1,3,5(10)-estratrien-3-ol; 17-beta-(5-hydroxy-1-pentylamino)-1,3,5(10)-estratrien-3-ol
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Amino Alcohols: 20
pentolame: 3
Alcohols: 595
Amino Alcohols: 20
pentolame: 3
Polycyclic Compounds: 6
Fused-Ring Compounds
Steroids: 70059
Estranes
Estrenes
pentolame: 3
Experts
1.
Canchola, E
: 1 article (03/2009)
2.
Lemini, C
: 1 article (03/2009)
3.
Canchola, Enrique
: 1 article (01/2009)
4.
Lemini, Cristina
: 1 article (01/2009)
Related Diseases
1.
Lordosis
01/01/2009 - "
This work evaluates the influence of single and multiple administration of a homologous series of the AEs: prolame, butolame and pentolame on rat female sexual behavior to explore their capability of inducing lordosis by themselves.
"
03/23/2009 - "
Dose-response curves were performed in rats by single subcutaneous (s.c.) injection (timezero) of: E2 (approximately 0.3, 3, 30, 60, 300 microg/kg); EB (approximately 0.4, 4, 40, 80, 400 microg/kg); prolame, butolame, pentolame (approximately 40, 400, 2000 or 4000 mg/kg), vehicle (corn oil; 300 microL/day; approximately 1.2 mL/kg) as control; 24 h after, P (1 mg/rat in 100 microL of corn oil; approximately 4 to 5 mg/kg) was administered, and 5 to 7 h later LQ was evaluated (number of lordosis displays/number of mounts x 100).
"
2.
Uterine Cervical Neoplasms (Cancer of the Cervix)
01/01/2022 - "
Thus, our data suggest that butolame and pentolame, but not prolame, could be used for HRT without presenting a potential risk of inducing breast- or cervical-cancer-cell proliferation.
"
01/01/2022 - "
Prolame induced cell proliferation in breast (MCF-7) and cervical cancer (SIHA) cells; meanwhile, butolame and pentolame did not affect cell proliferation.
"
Related Drugs and Biologics
1.
butolame
2.
prolame
3.
Corn Oil (Oil, Corn)