nuezhenide

from Ligustrum lucidum; structure given in first source; RN refers to trans-isomer

Also Known As:

specnuezhenide; 2-(4-hydroxyphenyl)ethyl-6-(3-ethylidene-2-(beta-D-glucopyranosyloxyl)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-acetate)-beta-D-glucopyranoside

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycosides: 2119
  - Glucosides: 639
    - nuezhenide: 6
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - nuezhenide: 6

Experts

1.	Wang, Wei: 2 articles (01/2018 - 12/2016)
2.	Chen, Haixia: 1 article (02/2022)
3.	Ding, Yi: 1 article (02/2022)
4.	Hu, Dongmei: 1 article (02/2022)
5.	Huang, Shaojie: 1 article (02/2022)
6.	Wang, Jingwen: 1 article (02/2022)
7.	Zhang, Wei: 1 article (02/2022)
8.	Zhao, Xian: 1 article (02/2022)
9.	Jia, Jian: 1 article (04/2020)
10.	Li, Qin: 1 article (04/2020)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 09/01/2023 - "Gut microbiota-based pharmacokinetic-pharmacodynamic study and molecular mechanism of specnuezhenide in the treatment of colorectal cancer targeting carboxylesterase."
2.	Inflammation (Inflammations) 09/01/2023 - "Specnuezhenide reduced cutaneous apoptosis and inflammation in mice with skin photoaging. " 01/01/2018 - "Specnuezhenide Decreases Interleukin-1β-Induced Inflammation in Rat Chondrocytes and Reduces Joint Destruction in Osteoarthritic Rats." 09/01/2023 - "Specnuezhenide (SNZ) is among the main components of Fructus Ligustri Lucidi, which has anti-inflammation, anti-oxidation, and anti-tumor effect. "
3.	Gestational Diabetes (Gestational Diabetes Mellitus) 04/20/2020 - "Protective effect of Specnuezhenide on islet β cell of rats with gestational diabetes mellitus."
4.	B-Cell Lymphoma (Lymphoma, B Cell) 02/01/2022 - "Finally, TUNEL staining and immunohistochemistry indicated that specnuezhenide prevented CCl4-induced hepatocytic apoptosis by up-regulating B-cell lymphoma 2 (Bcl-2) expression and downregulating Bcl-2-associated X (Bax) expression. "
5.	Neoplasms (Cancer) 09/01/2023 - "Specnuezhenide (SNZ) is among the main components of Fructus Ligustri Lucidi, which has anti-inflammation, anti-oxidation, and anti-tumor effect. "

Related Drugs and Biologics

1.	Carboxylesterase (Hydrolase S)
2.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
3.	Retinaldehyde (Retinal)
4.	Peanut Oil

Related Therapies and Procedures

1.	Oral Administration