centaureidin

structure given in first source; isolated from Tanacetum microphyllum, Brickellia veronicaefolia

Also Known As:

5,7,3'-trihydroxy-3,6,4'-trimethoxyflavone; 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6-dimethoxy-

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

1.	Neoplasms (Cancer) 01/01/2010 - "It was found that, apart from centaureidin (6), which is extremely active (IC(50) 0.082, 0.13, and 0.35 microM on the HeLa, MCF7, and A431 cell lines, respectively), all these compounds exert high or moderate tumor cell-growth inhibitory activity (IC(50) 3.42-58.15 microM)." 06/18/1998 - "A series of 79 flavones related to centaureidin (3,6,4'-trimethoxy-5, 7,3'-trihydroxyflavone, 1) was screened for cytotoxicity in the NCI in vitro 60-cell line human tumor screen. "
2.	Necrosis 01/01/2004 - "In the tumour necrosis factor-alpha (TNF-alpha) assay, only centaureidin and hydroxyachillin significantly inhibited the accumulation of TNF-alpha. "
3.	Edema (Dropsy) 11/01/2001 - "The compounds were identified as 5,7,5'-trihydroxy-3,6,2',4'-tetramethoxyflavone (1), scopoletin (2) and centaureidin (3) which inhibited the edema by 67.3 %, 59.8 % and 49.7 %, respectively, at a dose of 1 mg/ear."
4.	Confusion (Bewilderment) 09/01/2003 - "Bio-guided fractionation of an extract from Tanacetum parthenium showing activity as mitotic blocker allowed the isolation and identification of santin 3, jaceidin 2 and centaureidin 1. The latter two closely related flavonols, which, to the best of our knowledge, are isolated here together for the first time, form a mixture difficult to resolve and which is probably the reason for the confusion in the literature regarding their occurrence. "

1.	Flavones
2.	Flavonols
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4.	Scopoletin
5.	jaceidin
6.	santin
7.	hydroxyachillin