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BQ 485

an endothelin ET(A)receptor antagonist; structure given in first source

Also Known As:

BQ-485; perhydroazepin-1-yl leucyl-tryptophyl-tryptophan; perhydroazepin-1-yl-Leu-Trp-Trp

Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azepines: 11
    - BQ 485: 8
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - BQ 485: 8

Related Diseases

1.	Portal Hypertension 03/01/1996 - "The effects of portal hypertension on gastric secretory, motor, and mucosal functions were reversed by treatment with endothelin-A receptor blocker, BQ-485. " 03/01/1996 - "Control; sham-operated; endothelin-A receptor blocker, BQ 485 (1 microgram/kg)-treated; portal hypertensive; and portal hypertension +, endothelin-A receptor blocker-treated rats were subjected to tests of gastric secretory, motor, and mucosal function studies as well as gastric wall polymorphonuclear infiltration. "
2.	Reperfusion Injury 02/01/1999 - "Male Sprague Dawley rats were randomly divided into 4 groups: control (n = 10), bosentan (40 nM; n = 10), BQ-485 (20 nM; n = 10), and BQ-788 (50 nM; n = 10) to compare the effects of ETA or ETB or both ETA and ETB antagonists against the warm ischemia-reperfusion damage of murine livers. " 10/01/1999 - "Experiment 2: we determined the effects of ET antagonists on reperfusion injury after warm ischemia of 40 minute's cutoff of perfusate under propofol anesthesia and compared five groups up to 90 min after reperfusion; the propofol only group (control; 4 mg.l-1), the BQ-485 group (20 microM), the BQ-788 group (50 microM), the bosentan group (40 microM), and the BQ-485 + BQ-788 group. "
3.	Acute Kidney Injury (Acute Renal Failure) 10/01/1996 - "Treatment of LPS-rats with BQ-788, but not with BQ-485, attenuated the degree of liver injury and failure, while neither BQ-788 nor BQ-485 affected the acute renal failure or the induction of iNOS caused by endotoxin. "
4.	Intracranial Vasospasm 09/15/1993 - "A novel endothelin ETA receptor antagonist, BQ-485, and its preventive effect on experimental cerebral vasospasm in dogs."
5.	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 09/15/1993 - "We examined the preventive effect of a novel ETA receptor antagonist, BQ-485, on experimental vasospasm using canine two-hemorrhage model of subarachnoid hemorrhage. "

Related Drugs and Biologics

1.	Endothelin A Receptor
2.	salicylhydroxamic acid (SHAM)
3.	Bosentan (Tracleer)
4.	BQ 788
5.	Endothelins (Endothelin)
6.	Endothelin-1 (Endothelin 1)
7.	Propofol (Diprivan)
8.	Oxygen (Dioxygen)
9.	Endotoxins
10.	Collagen

Related Therapies and Procedures

1.	Warm Ischemia
2.	Anesthesia