azetidine-2,4-dicarboxylic acid

activates neuronal metabotropic receptors; RN given refers to (trans-isomer); RN for cpd without isomeric designation not avail 10/93

Also Known As:

AD-2,4-DC; azetidine-2,4-dicarboxylic acid, (cis)-isomer; trans-azetidine-2,4-dicarboxylic acid

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Tetanus 12/29/1995 - "In the presence of picrotoxin, a weak tetanus led to a short-term potentiation (STP) lasting 10-15 min. Application of the class I mGluR agonists trans-azetidine-2,4-dicarboxylic acid (tADA, 100 microM) or 3,5-dihydroxyphenylglycine (DHPG, 100 microM) for 15 or 30 min before the weak tetanus did not affect baseline synaptic transmission or the magnitude of the subsequent potentiation. "
2.	Hypoglycemia (Reactive Hypoglycemia) 10/01/1995 - "With the help of more subtype-specific agonists, we found that an activation of phospholipase C coupled (class 1) metabotropic glutamate receptors prior to hypoxia/hypoglycemia may be responsible for the protective effect seen with 1S, 3R-1-aminocyclopentane-1,3-dicarboxylic acid, because the specific class 1 metabotropic glutamate receptor agonist trans-azetidine-2,4-dicarboxylic acid appeared to be highly protective, but only if it was applied 20 min before the hypoxia/hypoglycemia. "
3.	Hypoxia (Hypoxemia) 10/01/1995 - "With the help of more subtype-specific agonists, we found that an activation of phospholipase C coupled (class 1) metabotropic glutamate receptors prior to hypoxia/hypoglycemia may be responsible for the protective effect seen with 1S, 3R-1-aminocyclopentane-1,3-dicarboxylic acid, because the specific class 1 metabotropic glutamate receptor agonist trans-azetidine-2,4-dicarboxylic acid appeared to be highly protective, but only if it was applied 20 min before the hypoxia/hypoglycemia. "

1.	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)
2.	Picrotoxin
3.	Type C Phospholipases
4.	Acids
5.	3,5-dihydroxyphenylglycine
6.	3,4-dihydroxyphenylglycol