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plachitin
combination of cisplatin & chitin; used for intraarterial chemoembolization therapy
Networked:
6
relevant articles (
2
outcomes,
2
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Macromolecular Substances: 97
Polymers: 13051
Biopolymers: 773
Chitin: 898
plachitin: 6
Carbohydrates: 22023
Polysaccharides: 15383
Chitin: 898
plachitin: 6
Inorganic Chemicals: 9
Platinum Compounds: 758
Cisplatin: 46373
plachitin: 6
Nitrogen Compounds: 67
Cisplatin: 46373
plachitin: 6
Chlorine Compounds: 8
Cisplatin: 46373
plachitin: 6
Pharmaceutical Preparations
Drug Combinations: 5337
plachitin: 6
Related Diseases
1.
Neoplasms (Cancer)
03/01/1995 - "
Local application of Plachitin improved the survival of mice previously implanted with Ehrlich tumor (p < 0.05).
"
08/01/1992 - "
When Plachitin was implanted around the solid tumor, the survival rates were improved and the gain in tumor weight was suppressed as compared with the controls.
"
08/01/1993 - "
From the above results it can be concluded that Plachitin particles released CDDP slowly around the tumor and the tumor growth was suppressed by the additive effect of CDDP and embolization.
"
08/01/1993 - "
Tumor regression was noticed only in the Plachitin group.
"
08/01/1993 - "
Plachitin was considered a useful agent for chemoembolization therapy for the cancer patients.
"
2.
Gastrointestinal Neoplasms (Gastrointestinal Cancer)
09/01/1995 - "
[Pharmacokinetic study of intraperitoneally administered plachitin for non-curative gastrointestinal cancer].
"
09/01/1995 - "
Pharmacokinetics and adverse effects of Plachitin for intraperitoneal chemotherapy (IP) were studied in 11 patients who suffered from non-curative gastrointestinal cancers in comparison with 4 patients who underwent IP of CDDP.
"
3.
Residual Neoplasm
09/01/1995 - "
Five patients were given 300 mg (100 mg as CDDP) of Plachitin which was cotton type on the residual cancer mass (Group A).
"
4.
Sarcoma (Soft Tissue Sarcoma)
08/01/1991 - "
Anticancer effect of Plachitin was investigated by injecting 180 sarcoma cells in mouse peritoneal cavity and subsequent implantation of Plachitin.
"
5.
Nausea
09/01/1994 - "
Adverse effects of Plachitin particles for arterial chemoembolization were epigastralgia, nausea, fever, and elevation of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels.
"
Related Drugs and Biologics
1.
Cisplatin (Platino)
2.
Chitin
3.
Aspartate Aminotransferases (Aspartate Transaminase)
4.
Alanine Transaminase (SGPT)
5.
Acetylglucosamine
Related Therapies and Procedures
1.
Therapeutics
2.
Drug Therapy (Chemotherapy)