retinoic acid receptor beta

Also Known As:

RAR beta; RAR-beta2 protein, rat; RARB protein, human; Rarb protein, mouse; Rarb protein, rat; retinoic acid receptor, beta, human; retinoic acid receptor, beta, mouse; retinoic acid receptor, beta, rat; retinoic acid receptor, beta2, rat; retinoic acid receptor-beta

Networked: 398 relevant articles (3 outcomes, 56 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - Retinoic Acid Receptors: 1114
      - retinoic acid receptor beta: 398
  - Cytoplasmic and Nuclear Receptors: 3987
    - Retinoic Acid Receptors: 1114
      - retinoic acid receptor beta: 398

Experts

1.	Lotan, R: 10 articles (10/2001 - 05/2000)
2.	Lotan, Reuben: 8 articles (01/2006 - 01/2002)
3.	Xu, X C: 7 articles (04/2001 - 05/2000)
4.	Fackler, Mary Jo: 5 articles (08/2010 - 12/2003)
5.	Sukumar, Saraswati: 5 articles (08/2010 - 12/2003)
6.	Argani, Pedram: 5 articles (09/2008 - 10/2003)
7.	Hong, W K: 5 articles (04/2001 - 05/2000)
8.	Lippman, S M: 5 articles (04/2001 - 03/2000)
9.	Fujiwara, Keiichi: 4 articles (09/2008 - 02/2005)
10.	Ueoka, Hiroshi: 4 articles (09/2008 - 02/2005)

Related Diseases

1.	Carcinogenesis 11/28/2006 - "These results suggest that 9cRA supplementation may provide protection against lung carcinogenesis and this effect may be mediated in part by 9cRA induction of RAR-beta, but not inhibition of COX-2 transcription." 01/01/2018 - "Although studies reported different rates for RAR beta promoter methylation in PCa tissues, the total analysis demonstrated that RAR beta promoter methylation may be correlated with PCa carcinogenesis and that the RAR beta gene is particularly susceptible. " 03/01/2004 - "Recent studies have demonstrated that retinoic acid receptor beta (RARbeta) plays a pivotal role from the early stages of laryngeal carcinogenesis; however, the exact mechanism of this detrimental effect has not yet been elucidated. " 11/01/2003 - "The purpose of this study was to investigate the mechanism of altered retinoic acid receptor beta (RARbeta) expression during esophageal squamous carcinogenesis. " 01/11/2011 - "Stromal retinoic acid receptor beta promotes mammary gland tumorigenesis."
2.	Prostatic Neoplasms (Prostate Cancer) 12/23/2014 - "Also this study revealed that reverse correlation of RAR beta 2, ER alpha, PGR, and RGMA expressions with EZH2, SRC3, and AR expressions in prostate cancer tissues suggests that these genes are the target of EZH2. " 12/23/2014 - "The study demonstrated that H3K27me3 level was significantly enriched at the RAR beta 2, ER alpha, PGR, and RGMA promoter regions in prostate cancer tissues compared to normal tissues. " 12/23/2014 - "In this study, the focus will be on histone modifications and the primary objectives are to map H3K27me3 marks and quantify RAR beta 2, ER alpha, SRC3, RGMA, PGR, and EZH2 gene expressions in prostate cancer tissues compared to normal tissues. " 01/01/2018 - "However, the connection between RAR beta promoter methylation and prostate cancer (PCa) remains unknown. " 01/01/2018 - "Clinical Significance of Retinoic Acid Receptor Beta Promoter Methylation in Prostate Cancer: A Meta-Analysis."
3.	Embryonal Carcinoma 12/01/1994 - "Retinoic acid (RA) activates transcription of the RA receptor beta 2 (RAR beta 2) gene in embryonal carcinoma (EC) cells. " 04/01/1993 - "The retinoic acid (RA) receptor (RAR) beta 2 promoter is strongly activated by RA in embryonal carcinoma (EC) cells. " 05/01/1992 - "In embryonal carcinoma (EC) cells retinoic acid (RA) strongly induces transcription from the RA receptor beta 2 (RAR beta 2) promoter through an RA response element (RARE) located in close proximity to the TATA box. " 03/01/1994 - "There are 3 families of RA receptors (RARs), RAR alpha, RAR beta and RAR gamma, each having at least two isoforms derived from primary transcripts initiated at two promoters P1 and P2 (reviewed in Leid et al., 1992) Transcripts encoding all 4 isoforms of RAR beta (RAR beta 1 to RAR beta 4) accumulate in embryonal carcinoma (EC) cells in the presence of RA. " 02/01/1995 - "Efficacy of all-trans-beta-carotene, canthaxanthin, and all-trans-, 9-cis-, and 4-oxoretinoic acids in inducing differentiation of an F9 embryonal carcinoma RAR beta-lacZ reporter cell line."
4.	Neoplasms (Cancer) 01/01/2018 - "Numerous studies have found that methylation of the RAR beta promoter contributed to the occurrence and development of malignant tumors. " 04/01/2004 - "These studies demonstrate that aberrant methylation of RAR-beta is an early and common alteration in murine lung tumors induced by several environmentally relevant exposures." 02/01/1993 - "To study the possible role of RAR beta in growth control of epidermoid lung tumor-derived cells, transfectants expresing RAR beta were generated from nonexpressing epidermoid tumor-derived cell lines. " 02/01/2011 - "The RAR beta gene methylation did not differ based on the smoking status of patients in tumor tissue. " 02/01/2011 - "RAR beta gene methylation in tumor tissue was associated with clinical type (P < 0.05) and tumor stage (P < 0.05) significantly. "
5.	Breast Neoplasms (Breast Cancer) 04/01/2019 - "We aimed to determine the promoter methylation status of the retinoic acid receptor-beta 2 (RARβ2) gene among breast cancer patients and to review relevant studies in this field in various populations. " 01/01/2022 - "The Sin3A/MAD1 Complex, through Its PAH2 Domain, Acts as a Second Repressor of Retinoic Acid Receptor Beta Expression in Breast Cancer Cells." 04/01/2019 - "Promoter Methylation Status of the Retinoic Acid Receptor-Beta 2 Gene in Breast Cancer Patients: A Case Control Study and Systematic Review." 10/28/2005 - "The retinoic acid receptor beta 2 (RARbeta2) gene modulates proliferation and survival of cultured human breast cancer cells. " 10/28/2005 - "Antimetastatic gene expression profiles mediated by retinoic acid receptor beta 2 in MDA-MB-435 breast cancer cells."

Related Drugs and Biologics

1.	Acids
2.	beta Carotene (Betacarotene)
3.	Retinoic Acid Receptor alpha
4.	Canthaxanthin
5.	retinoic acid receptor beta
6.	Retinoids
7.	Tretinoin (Retinoic Acid)
8.	Retinoic Acid Receptor gamma
9.	Cadherins (E-Cadherin)
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Chemoprevention
2.	Drug Therapy (Chemotherapy)
3.	Therapeutics
4.	Radiotherapy
5.	Neoadjuvant Therapy