Candida albicans ECE1 protein

06/01/2023 - "In this study, we determined the expression pattern of TREM-1 in a mouse model of Candida albicans corneal keratitis and investigated the molecular mechanism underlying the inflammatory response regulation by candidalysin. "
06/01/2023 - "Moreover, it remains unclear whether candidalysin regulates the inflammatory response through the TREM-1/DAP12 pathway in Candida albicans corneal keratitis. "
06/01/2023 - "However, the role of candidalysin in Candida albicans corneal keratitis remains unexplored. "
06/01/2023 - "Candidalysin amplifies the immune inflammatory response in Candida albicans keratitis through the TREM-1/DAP12 pathway."
06/01/2023 - "These data suggest that candidalysin can initiate inflammatory response in Candida albicans corneal keratitis through the TREM-1/DAP12 pathway and can regulate cytokine expression by enhancing ERK phosphorylation."

01/01/2022 - "Candidalysin is secreted by Candida albicans and is critical for driving infection and host immune responses in several model systems. "
01/01/2022 - "Previous work showed that candidalysin damages the cell membrane to promote infection. "
12/01/2019 - "Candidalysin is critical for mucosal and systemic infections and is a key driver of host cell activation, neutrophil recruitment and Type 17 immunity. "
12/01/2019 - "Candidalysin: discovery and function in Candida albicans infections."
01/01/2019 - "The data demonstrate a key role for candidalysin in neutrophil recruitment and fungal virulence during disseminated systemic C albicans infections."

01/01/2021 - "Candida albicans and candidalysin in inflammatory disorders and cancer."
10/11/2022 - "albicans immature cytolytic toxin candidalysin to develop a less hemolytic peptide with anti-neuroinflammatory, antibacterial, and cytotoxic activity against tumor cells. "
10/01/2020 - "This review discusses the recent epidemiological burden of oral cancer and highlights the significance of the ECE1 gene and the ECE1 protein breakdown product, candidalysin in oral malignancy. "
10/01/2020 - "The immunological and molecular mechanisms behind oral malignancy induced by inflammation and the role of the toxic fungal peptide candidalysin in oral carcinogenesis are explored. "

11/03/2017 - "albicans, via secreted candidalysin, amplify inflammation in a self-reinforcing feed-forward loop. "
10/01/2020 - "The immunological and molecular mechanisms behind oral malignancy induced by inflammation and the role of the toxic fungal peptide candidalysin in oral carcinogenesis are explored. "
01/01/2022 - "The fungal pathogen Candida albicans secretes the peptide toxin candidalysin, which damages epithelial cells and drives an innate inflammatory response mediated by the epidermal growth factor receptor (EGFR) and mitogen-activated protein kinase (MAPK) pathways and the transcription factor c-Fos. "

01/01/2019 - "albicans and candidalysin activate human epithelial EGFR receptors and candidalysin-deficient fungal mutants poorly induce EGFR phosphorylation during murine oropharyngeal candidiasis. "
01/01/2018 - "C. albicans strains harboring mutations of Arg61 and/or Arg93 did not secrete candidalysin, were unable to induce epithelial damage and inflammatory responses in vitro, and showed attenuated virulence in vivo in a murine model of oropharyngeal candidiasis. "
11/03/2017 - "Candidalysin-induced epithelial cell damage promotes expansion of innate TCRαβ+ cells during oropharyngeal candidiasis."
01/01/2019 - "We thus identify a PAMP-independent mechanism of immune stimulation and highlight candidalysin and EGFR signalling components as potential targets for prophylactic and therapeutic intervention of mucosal candidiasis."