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tylosin reductase

from Streptomyces fradiae; catalyzes the reduction of tylosin to relomycin in the presence of NADPH; MW 270 kDa; inhibited by FAD or FMN; shows a broad substrate specificity toward all macrolide aldehydes; may have physiological role of macrolide detoxification for the bacterium; structure of tylosin & relomycin given in first source
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