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metrifudil
Also Known As:
N-((2-methylphenyl)methyl)adenosine; Y 341; Y-341
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Purines: 651
Purine Nucleosides: 360
Adenosine: 12431
metrifudil: 4
Nucleic Acids, Nucleotides, and Nucleosides: 1
Nucleosides: 6847
Purine Nucleosides: 360
Adenosine: 12431
metrifudil: 4
Ribonucleosides: 49
Adenosine: 12431
metrifudil: 4
Related Diseases
1.
Apnea
11/01/1994 - "
The A2a agonists CGS21680 and CV1808 showed no discernible activity at the A3 receptor, whereas APNEA,NECA, CPA and metrifudil appear to activate this receptor.
"
12/01/1994 - "
The compounds tested were the non-selective adenosine receptor agonist 5'-N-ethyl-carboxamidoadenosine (NECA), the adenosine A1 receptor-selective agonists cyclopentyl-adenosine (CPA), N6-(9R-phenyl-isopropyl)-adenosine (R-PIA) and N-(1S,trans)-[2-hydroxyclopentyl]-adenosine (GR79236), the A2a receptor selective agonist 2-[p-(2-carboxyethyl)phenethylamino]-5'-N-ethylcarboxyamidoaden osine (CGS-21680), the A2b receptor agonist N-[(2-methylphenyl)methyl[adenosine (metrifudil) and the A3 receptor agonist N6-(4-aminophenylethyl)adenosine (APNEA).
"
11/01/1994 - "
The compounds tested were: the A1/A3 receptor agonist, N-[2-(4-aminophenyl)ethyl]adenosine (APNEA), the non-selective adenosine receptor agonist, 5'-N-ethylcarboxamidoadenosine (NECA), the adenosine A1 receptor-selective agonists, N-[(1S,trans)-2-hydroxycyclopentyl]adenosine (GR79236) and N6-cyclopentyl adenosine (CPA), the A2a receptor-selective agonists, 2-[[2-[4-(2-carboxyethyl) phenyl] ethyl] amino]-N- ethylcarboxamidoadenosine (CGS21680) and 2-phenylaminoadenosine (CV1808), and the moderately A2b selective agonist, N-[(2-methylphenyl)methyl]adenosine (metrifudil).
"
2.
Seizures (Absence Seizure)
10/05/1993 - "
Likewise, the selective adenosine A2 receptor agonists N-[(2-methylphenyl)methyl]adenosine (metrifudil) and N-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]adenosine (DPMA), in doses of 30 and 100 mg/kg i.p., respectively, potentiated seizures induced by the selective adenosine A2 receptor antagonist 3,7-dimethyl-1-propargylxanthine (DMPX).
"
3.
Hypothermia
12/01/1994 - "
However, CGS-21680 (0.1-10 micrograms i.c.v.) and metrifudil (0.01-1 microgram i.c.v.), produced only mild hypothermia at the highest doses tested.
"
4.
Hypotension (Low Blood Pressure)
11/01/1994 - "
The hypotension induced by metrifudil was not antagonized by either 8-sPT (40 mg kg-1) or CGS15943A (3 mg kg-1) even though the bradycardia was abolished, suggesting that this agonist activates the putative A3 receptor.6. The non-selective adenosine receptor agonist, NECA, produced a hypotension and bradycardia that was attenuated by 8-sPT (40 mg kg-1), confirming previous work.
"
5.
Glomerulonephritis
09/08/1972 - "
[Treatment of glomerulonephritis with metrifudil.
"
Related Drugs and Biologics
1.
Adenosine (Adenocard)
2.
Adenosine A1 Receptor
3.
Adenosine-5'-(N-ethylcarboxamide) (NECA)
4.
Purinergic P1 Receptors (Adenosine Receptor)
5.
N- ((1S,trans)- 2- hydroxycyclopentyl)adenosine
6.
Adenosine A2 Receptor Agonists
7.
Adenosine A2 Receptors
8.
2- (4- (2- carboxyethyl)phenethylamino)- 5'- N- ethylcarboxamidoadenosine
9.
3,7-dimethyl-1-propargylxanthine
10.
CGS 24012 (DPMA)
Related Therapies and Procedures
1.
Controlled Hypotension