CRKL protein

human crk-like gene product; 303 amino acid residues, MW 36 kDa; potentially capable of mediating the transduction of intracellular signals; located on chromosome 22; amino acid sequence given in first source

Also Known As:

Networked: 15 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Yang, Qing: 2 articles (01/2017 - 02/2015)
2.	Wang, Yan: 2 articles (02/2015 - 11/2013)
3.	Lv, Shunzeng: 2 articles (06/2014 - 11/2013)
4.	Yao, Chengjun: 2 articles (06/2014 - 11/2013)
5.	Yi, Ruiyang: 2 articles (06/2014 - 11/2013)
6.	Bartochowska, Anna: 1 article (01/2020)
7.	Bednarek, Kinga: 1 article (01/2020)
8.	Bodnar, Magdalena: 1 article (01/2020)
9.	Filas, Violeta: 1 article (01/2020)
10.	Giefing, Maciej: 1 article (01/2020)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2020 - "Beside the physiological cytoplasmic expression, the analysis of LSCC tumor samples revealed also nuclear expression of CRKL protein in 10/40 (25%) cases, of which three (7.5%), presented moderate or strong nuclear expression. " 01/01/2019 - "Compared with the matched adjacent non-tumor tissues, CrkL protein expression level was significantly up-regulated in tumor tissues. " 01/01/2017 - "The v-Crk avian sarcoma virus CT10 oncogene homolog-like (CRKL) protein is important in cancer progression. " 10/01/2013 - "CRKL protein was upregulated in the cancer tissues compared with adjacent normal mammary glands. " 10/01/2013 - "However, the expression pattern of CRKL protein and its clinical significance in human breast cancers have not been well characterized. "
2.	Stomach Neoplasms (Stomach Cancer) 01/01/2019 - "However, the expression pattern of CrkL protein and its clinical significance have not been well characterized in human gastric cancer (GC) so far. " 07/03/2012 - "These results suggested that CRKL protein is overexpressed in a subset of gastric cancers and is associated with CRKL amplification in gastric cancer. " 07/03/2012 - "An immunohistochemical analysis revealed that CRKL protein was overexpressed in 24.4% (88/360) of the primary gastric cancers that were analyzed. " 07/03/2012 - "Furthermore, our results suggested that CRKL protein has the ability to regulate gastric cell proliferation and has the potential to serve as a molecular therapy target for gastric cancer."
3.	Carcinoma (Carcinomatosis) 11/01/2016 - "CrkL protein expression was examined in tissue samples from 92 cases of cervical carcinoma using immunohistochemistry, and was found to be overexpressed in 48.9% (45/92 cases). " 11/01/2013 - "CRKL protein was up-regulated in the lung carcinomas compared with adjacent normal lung tissue. "
4.	Endometrial Neoplasms (Endometrial Cancer) 01/01/2017 - "Using immunohistochemistry, it was observed that the CRKL protein was overexpressed in 50.5% (44/87) of endometrial carcinoma tissues. "
5.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/01/2011 - "[Clinical significance of CRKL protein phosphorylation level in the treatment of chronic myeloid leukemia with imatinib]."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Stathmin
3.	Doxorubicin (Adriamycin)
4.	DNA (Deoxyribonucleic Acid)
5.	Imatinib Mesylate (Gleevec)

Related Therapies and Procedures

1.	Therapeutics