HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

4- amino- 8- (ribofuranosylamino)pyrimido(5,4- d)pyrimidine- 5'- phosphate

structure given in first source; RN given refers to (beta-D)-isomer

Also Known As:

APP-MP

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidine Nucleotides: 48
      - 4-amino-8-(ribofuranosylamino)pyrimido(5,4-d)pyrimidine-5'-phosphate: 1
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 15763
  - Pyrimidine Nucleotides: 48
    - 4-amino-8-(ribofuranosylamino)pyrimido(5,4-d)pyrimidine-5'-phosphate: 1

Related Diseases

1.

Experimental Liver Neoplasms

08/01/1993 - "This result was consistent with APP-MP acting as an inhibitor of 5-phosphoribosyl-1-pyrophosphate (PRPP) synthetase, a hypothesis that was confirmed by preparing PRPP synthetase from Novikoff hepatoma cells; APP-MP was a noncompetitive inhibitor, with a Ki of 0.43 mM. APP-MP was found to accumulate in APP-treated cells to a concentration of almost 3 mM. The relevance of PRPP synthetase inhibition to the cytotoxic mechanism of APP is indicated by the fact that depletion of the PRPP pool was seen as early as 15 min after treatment, before any change was apparent in cellular levels of ATP or UTP. "

Related Drugs and Biologics

1.	Uridine Triphosphate (UTP)
2.	Ribose-Phosphate Pyrophosphokinase (Phosphoribosyl Pyrophosphate Synthetase)
3.	Adenosine Triphosphate (ATP)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)