|1.||Basu, H S: 1 article (02/2001)|
|2.||Frydman, B: 1 article (02/2001)|
|3.||Marton, L J: 1 article (02/2001)|
|4.||Valasinas, A: 1 article (02/2001)|
|5.||Sarkar, A: 1 article (02/2001)|
|6.||Reddy, V K: 1 article (02/2001)|
|1.||Prostatic Neoplasms (Prostate Cancer)
01/01/1997 - "The proliferation of DU145, LNCaP and PC-3 prostate cancer cell lines was inhibited in a dose-dependent manner by BE-4-4-4-4. "
01/01/1998 - "These initial studies demonstrate that BE-4-4-4-4 is cytotoxic against rat and human prostate cancer cells in culture and effective against DuPro-1 xenografts in nude mice. "
02/01/2001 - "cis-Unsaturated analogues of 3,8,13,18,23-pentaazapentacosane (BE-4-4-4-4): synthesis and growth inhibitory effects on human prostate cancer cell lines."
01/01/1997 - "These results show the polyamine analogues BE-4-4-4-4, BE-3-3-3 and BE-3-7-3 to be effective inhibitors of prostate cancer cell growth in vitro and BE-4-4-4-4 to be an effective inhibitor of DU145 cells in vivo with minimal toxicity."
01/01/1997 - "Effects of the polyamine analogues BE-4-4-4-4, BE-3-7-3, and BE-3-3-3 on the proliferation of three prostate cancer cell lines."
|2.||Brain Neoplasms (Brain Tumor)
09/01/1994 - "The SF-767 brain tumors were extremely responsive to BE-4-4-4-4 alone (3 of 8 complete regressions after 2 cycles); however, the growth of the U-87 MG brain tumor was only slightly inhibited by BE-4-4-4-4 treatment. "
09/01/1993 - "Studies in U-87 MG, U-251 MG, SF-126, SF-188, SF-763, SF-767, and DAOY human brain tumor cells in tissue culture showed that treatment for more than 96 h with concentrations of 5 microM BE-4-4-4-4 or greater inhibited growth; decreased levels of putrescine, spermidine, and spermine; and decreased colony-forming ability in all cell lines. "
|3.||Carcinoid Tumor (Carcinoid)
12/01/1998 - "The purpose of our study was to determine whether BE-4-4-4-4 is a more effective antiproliferative and cytotoxic agent than DFMO on human carcinoid (BON) cells in vitro. "
12/01/1998 - "Polyamine analogs such as BE-4-4-4-4 may be effective adjuvant therapeutic agents for advanced carcinoid tumors."
12/01/1998 - "Synthetic polyamine analogs such as 1,19-bis(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) appear to be cytotoxic against several human tumors. "
01/01/1998 - "There was a significant inhibition of DuPro-1 tumors for animals treated with BE-4-4-4-4 compared with control animals. "
01/01/1997 - "BE-4-4-4-4 levels were highest in tumors on day 63 with levels reaching 0.33 and 1.45 nmol/mg protein from animals treated at the 3 mg/kg and 5 mg/kg doses, respectively. "
01/01/1997 - "Animals receiving BE-4-4-4-4 showed inhibition of tumor growth which continued throughout the experiment with 74% (3 mg/kg) and 81% (5 mg/kg) growth inhibition seen on day 101. "
06/15/1995 - "These data evaluate cytostatic and cytotoxic properties of the polyamine analog BE-4-4-4-4 in human SCCs, and suggest a role for investigation of such agents as an adjuvant to radiation in the therapeutic approach to rapidly dividing human tumors such as those that occur in the H&N."
|5.||Squamous Cell Carcinoma (Epidermoid Carcinoma)
09/01/1996 - "Xenografts of human squamous cell carcinomas were grown in nude mice; then, BE 4444 was injected intraperitoneally (5 mg/kg) on a twice-daily schedule for 8 days. "
09/01/1996 - "To evaluate the PA analogue BE 4444 for its inhibitory effect on the growth of human squamous cell carcinoma xenografts in nude mice. "
09/01/1996 - "Growth inhibition of squamous cell carcinoma xenografts with the polyamine analogue BE 4444."
06/15/1995 - "Slowing proliferation in head and neck tumors: in vitro growth inhibitory effects of the polyamine analog BE-4-4-4-4 in human squamous cell carcinomas."
|8.||Adenocarcinoma of lung
|9.||1,15- bis(ethylamino)- 4,12- diazapentadecane
|1.||Heterologous Transplantation (Xenotransplantation)