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3-hydroxy-5-oxo-5,6-secocholestan-6-al

structure given in first source

Also Known As:

3-HOSCA; ChSeco; cholesterol secoaldehyde

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Secosteroids: 22
      - 3-hydroxy-5-oxo-5,6-secocholestan-6-al: 5
    - Cholestanes
      - Cholestanones
        3-hydroxy-5-oxo-5,6-secocholestan-6-al: 5

Experts

1.	Uppu, Rao M: 5 articles (09/2021 - 06/2007)
2.	Raghavamenon, Achuthan C: 4 articles (09/2021 - 11/2009)
3.	Gao, Xueli: 2 articles (09/2021 - 11/2009)
4.	D'Auvergne, Oswald: 2 articles (01/2011 - 11/2009)
5.	Sathishkumar, K: 2 articles (01/2010 - 06/2007)
6.	Atkins-Ball, Deidra S: 1 article (09/2021)
7.	Achuthan, Vinitha: 1 article (01/2011)
8.	Laynes, Laura: 1 article (01/2011)
9.	Ganeshkumar, Karunakaran: 1 article (01/2010)
10.	Parinandi, Narasimham L: 1 article (01/2010)

Related Diseases

1.	Atherosclerotic Plaque (Atheroma) 11/13/2009 - "It is suggested that the apoptotic process is mediated via the mitochondrial pathway and that ChSeco formed in biological environments contributes to the initiation, progression, and culmination of atherosclerotic plaque formation, as these processes are critically dependent on macrophage apoptosis." 09/01/2021 - "Since inflammation is a key event at all stages of atherosclerotic plaque formation, the pro-inflammatory actions of ChSeco in human THP-1 monocytes and mouse J774 macrophages were investigated in the present study by employing ELISA, qRT-PCR, and functional assays. " 01/07/2011 - "3β-Hydroxy-5,6-secocholestan-6-al (cholesterol secoaldehyde or ChSeco), an oxysterol known to be formed in ozone- and singlet oxygen-mediated oxidations of cholesterol, has been detected in the atherosclerotic plaque and in the brain of patients suffering from Alzheimer's disease and Lewy body dementia. "
2.	Inflammation (Inflammations) 09/01/2021 - "Since inflammation is a key event at all stages of atherosclerotic plaque formation, the pro-inflammatory actions of ChSeco in human THP-1 monocytes and mouse J774 macrophages were investigated in the present study by employing ELISA, qRT-PCR, and functional assays. "
3.	Alzheimer Disease (Alzheimer's Disease) 01/01/2010 - "The real-time RT-PCR-based methodology presented here allows simultaneous detection and analysis of as many as 84 well-characterized genes associated with either oxidative stress or apoptosis in hypothalamic neuronal cells exposed to cholesterol secoaldehyde, an "ozone-/singlet oxygen-specific" oxidation product of cholesterol that has been shown to be present at the inflammatory sites including the arterial plaque and the brain specimens of patients with Alzheimer's disease. " 01/07/2011 - "3β-Hydroxy-5,6-secocholestan-6-al (cholesterol secoaldehyde or ChSeco), an oxysterol known to be formed in ozone- and singlet oxygen-mediated oxidations of cholesterol, has been detected in the atherosclerotic plaque and in the brain of patients suffering from Alzheimer's disease and Lewy body dementia. "
4.	Lewy Body Disease (Lewy Body Dementia) 01/07/2011 - "3β-Hydroxy-5,6-secocholestan-6-al (cholesterol secoaldehyde or ChSeco), an oxysterol known to be formed in ozone- and singlet oxygen-mediated oxidations of cholesterol, has been detected in the atherosclerotic plaque and in the brain of patients suffering from Alzheimer's disease and Lewy body dementia. "
5.	Neurodegenerative Diseases (Neurodegenerative Disease) 06/01/2007 - "However, since Alzheimer's and other neurodegenerative diseases are slow and progressive, the formation of Abeta aggregates in vivo by ChSeco may have long-term pathological consequences."

Related Drugs and Biologics

1.	Singlet Oxygen
2.	Ozone
3.	Cholesterol
4.	3-hydroxy-5-oxo-5,6-secocholestan-6-al
5.	Oxysterols