|1.||Auta, James: 7 articles (03/2012 - 03/2004)|
|2.||Guidotti, Alessandro: 6 articles (12/2011 - 03/2004)|
|3.||Costa, Erminio: 5 articles (03/2011 - 03/2004)|
|4.||Kadriu, Bashkim: 4 articles (12/2011 - 09/2008)|
|5.||Davis, John M: 3 articles (12/2011 - 07/2005)|
|6.||Nambiar, Madhusoodana P: 2 articles (03/2012 - 12/2011)|
|7.||Guidotti, A: 2 articles (01/2004 - 11/2002)|
|8.||Grayson, D R: 2 articles (01/2004 - 11/2002)|
|9.||Costa, E: 2 articles (01/2004 - 11/2002)|
|10.||Wood, Elisa: 1 article (03/2012)|
12/01/2011 - "Absence of tolerance to the anticonvulsant and neuroprotective effects of imidazenil against DFP-induced seizure and neuronal damage."
01/01/2000 - "It was stated that imidazenil (i) significantly decreased convulsion intensity in mice, (ii) quickly inhibited seizure patterns in bioelectrical activity in the rat's brain, (iii) significantly increased antilethal effectiveness of the standard therapy in mice intoxicated with DFP. "
01/01/2000 - "Effects of imidazenil, a new benzodiazepine receptor partial agonist, in the treatment of convulsions in organophosphate intoxications."
04/01/1994 - "Accordingly, imidazenil also showed great potency in antagonizing the convulsions induced by pentylenetetrazole in rats. "
04/01/1994 - "Moreover, imidazenil at a dose as low as 0.05 mg/kg (i.p.) delayed the onset of convulsions and death elicited by isoniazid and reduced significantly the number of mice exhibiting seizures. "
10/01/1998 - "However, imidazenil (2.5 micromol/kg i.p.) fails to reduce spontaneous locomotor activity, whereas diazepam (4.4 micromol/kg i.p.) elicits sedation and ataxia and clearly impairs spontaneous locomotor activity. "
09/01/1999 - "In the punished drinking, the punished lever pressing and the elevated plus-maze tests in rats, three models of anxiety, diazepam, clobazam and imidazenil elicited clear anxiolytic-like effects but at doses which were close to those producing hypolocomotion, ataxia and myorelaxation as measured in activity cages, the rotarod and the loaded grid tests, respectively. "
06/01/1995 - "Data in rats indicate that imidazenil, like alprazolam, has pharmacological effects in animals indicative of anxiolytic, antipanic and anticonvulsant activity in humans, but unlike alprazolam, in animals imidazenil does not produce ataxia, sedation, tolerance or dependence nor does it potentiate the effects of ethanol. "
08/01/1993 - "In all tests, imidazenil has the pharmacological profile of a partial allosteric modulator, but is more potent than bretazenil, has a longer biological half-life and, in rodents, is virtually unable to cause sedation, ataxia or to potentiate ethanol toxicity."
01/01/1998 - "Partial agonists (such as imidazenil), which modestly amplify GABA action at many GABAA receptor subtypes, fail to cause tolerance, dependence, ataxia, or ethanol and barbiturate potentiation. "
04/01/1994 - "Imidazenil also completely abolished the increase in [35S]TBPS binding induced by foot-shock or exposure to carbon dioxide. "
09/01/1994 - "Discontinuation of long-term treatment with diazepam or triazolam, but not of long-term treatment with imidazenil or bretazenil, sensitized rats to behavioral inhibition by punishment (electric shock) in a manner that was potentiated by flumazenil. "
04/01/1995 - "Foot-shock stress (0.2 mA for 500 msec/sec) delivered for 8 min induced a rapid and marked (+75%) increase in hippocampal acetylcholine output that persisted for approximately 40 min. Foot-shock stress also increased dopamine release in the cerebral cortex; the effect was maximal (+90%) after 20 min and persisted for approximately 30 min. Prior administration of abecarnil or imidazenil at a dose (0.05 mg/kg) that did not significantly affect the basal release of either acetylcholine or dopamine completely prevented the effect of stress on the output of these neurotransmitters, an effect mimicked by higher doses of diazepam (2.5 mg/kg) and midazolam (2.5 mg/kg).(ABSTRACT TRUNCATED AT 250 WORDS)"
|4.||Amnesia (Dissociative Amnesia)
03/01/2004 - "Moreover, imidazenil was effective at doses (1 and 0.5 mg/kg) we have previously shown to be devoid of sedation, amnesia, respiratory depression, or tolerance and/or dependence. "
01/01/1996 - "In rats subjected to a delayed object recognition test, diazepam, endowed with FAM activity, exerted an amnesic action, whereas BZs endowed with partial allosteric modulatory (PAM) activity on GABAA receptors, such as imidazenil, failed to induce amnesia, even if administered at doses five times higher than those equipotent to a standard anticonvulsant dose of diazepam (17.6 mumol/kg/os). "
07/01/2005 - "In contrast, other BZ-binding site ligands, such as 6-(2bromophenyl)-8-fluoro-4H-imidazo [1,5-a][1,4] benzodiazepine-3-carboxamide (imidazenil), which fail to allosterically and positively modulate the action of GABA at GABA(A) receptors with alpha(1) subunits but that selectively allosterically modulate cortical GABA(A) receptors containing alpha(5) subunits, contribute to the anxiolytic, antipanic, and anticonvulsant actions of these ligands without producing sedation, amnesia, or tolerance. "
01/01/2000 - "Three days after ischemia, six out of eight gerbils treated with imidazenil showed partial to complete neuroprotection. "
01/01/2000 - "Diazepam (10mg/kg, i.p.) or the partial agonist imidazenil (3mg/kg, i.p.) was administered 30 and 90min after transient forebrain ischemia produced by occlusion of the carotid arteries for 5min. "
05/01/1998 - "The ischemia-induced deficits in working memory were completely prevented by diazepam but not by imidazenil. "
05/01/1998 - "Imidazenil neuroprotection was lost when the drug was administered as early as 2 hours after ischemia. "
05/01/1998 - "Imidazenil (3 mg/kg), which produced only minimal hypothermia, protected area CA1 of hippocampus to the same degree as that by diazepam 7 days after ischemia. "
|3.||gamma-Aminobutyric Acid (GABA)
|4.||fluorophosphate (sodium monofluorophosphate)
|5.||GABA-A Receptors (GABA(A) Receptor)
|9.||Ethanol (Ethyl Alcohol)