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O-ethyl O-4-nitrophenyl phosphoramidate

a short-acting anticholinesterase & a possible candidate for a prophylactic agent against chemical warfare nerve agents

Also Known As:

ENPP

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Borza, Razvan: 1 article (01/2022)
2.	Moolenaar, Wouter H: 1 article (01/2022)
3.	Perrakis, Anastassis: 1 article (01/2022)
4.	Salgado-Polo, Fernando: 1 article (01/2022)
5.	Afantitis, Antreas: 1 article (01/2020)
6.	Aidinis, Vassilis: 1 article (01/2020)
7.	Gerokonstantis, Dimitrios Triantafyllos: 1 article (01/2020)
8.	Kokotos, George: 1 article (01/2020)
9.	Magkrioti, Christiana: 1 article (01/2020)
10.	Moutevelis-Minakakis, Panagiota: 1 article (01/2020)

Related Diseases

1.	Genetic Predisposition to Disease (Genetic Predisposition) 04/01/2008 - "However, not all patients will not develop DR, suggesting the presence of a genetic predisposition to DR, especially for severe forms of DR. Special strategies has been used to evaluate the genetic role in DR. Family studies shown that there is a familial aggregation of DR. Candidates genes have been studied (RAGE; VEGF; PPAR-delta; ICAM-1; ECA; ENPP 1; eNOS) and positive or negative associations with DR were demonstrated. "
2.	Neoplasms (Cancer) 01/01/2022 - "Ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family members (ENPP1-7) have been implicated in key biological and pathophysiological processes, including nucleotide and phospholipid signaling, bone mineralization, fibrotic diseases, and tumor-associated immune cell infiltration. " 03/01/2002 - "The levels of some organochlorine pesticides (OCP)s (hexachlorobenzene, HCB, alpha-hexachlorocyclohexane, alpha-HCH, beta-HCH, gamma-HCH, heptachlorepoxide, HE, bis (4-chlorophenyl)-1,1-dichloroethene, p.p'DDE, bis (4-chlorophenyl)-1,1,1-trichloroethane, p.p' DDT and total DDT (E-DDT) and antioxidant enzyme activities namely Cu, Zn superoxide dismutase (SOD), catalase (CAT), selenium-dependent glutathione peroxidase (Se-GSH-Px), total glutathione peroxidase (T-GSH-Px), selenium independent glutathione peroxidase (GSH-Px II), glutathione reductase (GRd), level of reduced glutathione (GSH) and lipid peroxidation (LP), glutathione S-transferase (GST) activity toward several substrates including 1-chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitrobenzene (DCNB), ethacrynic acid (EAA), 1,2-epoxy-3-(p-nitrophenoxy)-propane (ENPP) were measured in tumor and surrounding tumor free tissues of 24 female breast cancer patients and was evaluated whether there exist any association between the levels of OCPs and antioxidants. "
3.	Lung Injury 12/01/2015 - "Lysophosphatidic acid generation by pulmonary NKT cell ENPP-2/autotaxin exacerbates hyperoxic lung injury."
4.	Melanoma (Melanoma, Malignant) 01/01/2020 - "Autotaxin (ATX), a glycoprotein (~125 kDa) isolated as an autocrine motility factor from melanoma cells, belongs to a seven-membered family of ectonucleotide pyrophosphatase/phosphodiesterase (ENPP), and exhibits lysophospholipase D activity. "
5.	Insulin Resistance 08/15/2009 - "Suppression of PC-1/ENPP-1 expression improves insulin sensitivity in vitro and in vivo."

Related Drugs and Biologics

1.	PPAR delta
2.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
3.	Phosphoric Diester Hydrolases (Phosphodiesterases)
4.	Nucleotides
5.	Selenium
6.	Messenger RNA (mRNA)
7.	Pyrophosphatases
8.	Proteins (Proteins, Gene)
9.	Propane
10.	Phosphoric Monoester Hydrolases (Phosphatases)