verucopeptin

structure given in first source; isolated from Actinomadura verrucosospora; 19-membered cyclodepsipeptide

Also Known As:

Glycine, 3-hydroxy-N-(2-hydroxy-1-oxo-2-(tetrahydro-2-hydroxy-5-methoxy-6-(1,3,5,7-tetramethyl-1-nonenyl)-2H-pyran-2-yl)propyl)leucylhexahydro-3-pyridazinecarbonyl-N-hydroxyglycyl-N-methylglycylglycyl-N-methyl-, rho-lactone

Networked: 6 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Benes, Cyril H: 1 article (11/2020)
2.	Bray, Walter M: 1 article (11/2020)
3.	Chen, Lanfen: 1 article (11/2020)
4.	Crawford, Jason M: 1 article (11/2020)
5.	Dastur, Anahita: 1 article (11/2020)
6.	Deng, Xianming: 1 article (11/2020)
7.	Greninger, Patricia: 1 article (11/2020)
8.	Guh, Jih-Hwa: 1 article (11/2020)
9.	Hu, Zhiyu: 1 article (11/2020)
10.	Huang, Wei: 1 article (11/2020)

Related Diseases

1.	Neoplasms (Cancer) 12/06/2022 - "Convergent synthesis of tetrahydropyranyl side chain of verucopeptin, an antitumor antibiotic active against multidrug-resistant cancers." 10/01/2019 - "Verucopeptin is an inhibitor of hypoxia-inducible factor 1 (HIF-1), which is a promising target for cancer chemotherapy. " 11/19/2020 - "Verucopeptin exhibited strong inhibition of both v-ATPase activity and mTORC1 signaling, leading to substantial pharmacological efficacy against SGC7901/VCR cell proliferation and tumor growth in vivo. " 11/19/2020 - "(2020) identify the natural product verucopeptin as having therapeutic potential toward MDR cancer cell types by targeting v-ATPase and mTORC1 signaling." 12/06/2022 - "A concise synthesis of the tetrahydropyranyl side chain of verucopeptin, an antitumor antibiotic cyclodepsipeptide efficacious against MDR cancers in vivo, is achieved using 12 steps in the longest linear sequence and 21 total steps, in which Julia-Kocienski olefination for the segments coupling, asymmetric hydroxylation as well as stereoselective synthesis of stable tetrahydropyran ring from a D-isoascorbic acid derivative are key steps. "
2.	Experimental Melanoma 06/01/1993 - "Verucopeptin, a new antitumor antibiotic active against B16 melanoma. " 06/01/1993 - "Verucopeptin, a new antitumor antibiotic active against B16 melanoma. "

Related Drugs and Biologics

1.	Adenosine Triphosphatases (ATPase)
2.	Mechanistic Target of Rapamycin Complex 1
3.	Anti-Bacterial Agents (Antibiotics)
4.	Hypoxia-Inducible Factor 1
5.	Depsipeptides
6.	isoascorbic acid (erythorbic acid)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)