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fim 1

fluorescein-conjugated bis(indole)maleimide inhibitor of protein kinase C; can serve as useful fluorescent probe for protein kinase C

Also Known As:

fim-1

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Spiro Compounds: 2
      - Fluoresceins: 2
        fim 1: 4
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - fim 1: 4
  - 3-Ring Heterocyclic Compounds
    - Xanthenes: 65
      - Fluoresceins: 2
        fim 1: 4
Polycyclic Compounds: 6
- Spiro Compounds: 2
  - Fluoresceins: 2
    - fim 1: 4

Related Diseases

1.	Leukemia 01/01/1989 - "A number of putative oncogenes which are reported to play a role in Moloney and Friend virus induced leukemias for instance pim-1, fis-1, fim-1 and fim-2 were also used for screening. " 11/01/1988 - "Fim-1, Fim-2/c-fms, and Fim-3, three common integration sites of Friend murine leukemia virus in myeloblastic leukemias, map to mouse chromosomes 13, 18, and 3, respectively." 11/01/1986 - "fim-1 and fim-2: two new integration regions of Friend murine leukemia virus in myeloblastic leukemias."
2.	Myeloid Leukemia (Leukemia, Myelocytic) 11/01/1988 - "Three common proviral integration sites, Fim-1, Fim-2/c-fms, and Fim-3, have been described in mouse myeloid leukemias induced by the Friend murine leukemia virus. "
3.	Acute Erythroblastic Leukemia (Erythroleukemia) 08/01/1990 - "No alteration of the Fim-1, Fim-2, Fim-3, pvt-1, and Spi-1 loci were detected in 17 erythroleukemias, p53 gene rearrangement was observed in 6 (30%) erythroleukemias and was always associated with a loss of the germ line allele. "

Related Drugs and Biologics

1.	fim 2
2.	lambda Spi-1