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ICI D2788

a sinoatrial node modulator; may be of use in treatment of ischaemic heart disease by increasing heart rate without impairing cardiac function
Also Known As:
4-(N-ethyl-N-phenylamino)-1,2-dimethyl-6-(methylamino)pyrimidinium chloride; ICI-D2788; ZD 7288; ZD-7288; ZD7288; ZENECA ZD7288
Networked: 56 relevant articles (5 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Chen, Lucy: 3 articles (01/2018 - 01/2016)
2. Mao, Jianren: 3 articles (01/2018 - 01/2016)
3. Shen, Shiqian: 3 articles (01/2018 - 01/2016)
4. You, Zerong: 3 articles (01/2018 - 01/2016)
5. Wan, You: 3 articles (10/2008 - 01/2005)
6. Liu, Xiaohong: 2 articles (04/2022 - 01/2021)
7. Zeng, Junwei: 2 articles (04/2022 - 01/2021)
8. Onat, Filiz: 2 articles (01/2022 - 01/2018)
9. Çarçak, Nihan: 2 articles (01/2022 - 01/2018)
10. Sun, Yan: 2 articles (01/2019 - 01/2016)

Related Diseases

1. Hyperalgesia
2. Neuralgia (Stump Neuralgia)
3. Alcoholism (Alcohol Abuse)
4. Pain (Aches)
06/04/2015 - "Therefore, in the present study we used the mSNA model to investigate whether: (a) expression of HCN1-HCN3 channels is altered in L4 DRG neurons which, in the mSNA model, are essential for transmission of the evoked pain, and which contribute to chronic spontaneous pain, and (b) local (intraplantar) blockade of these HCN channels, with a specific blocker, ZD7288, attenuates chronic spontaneous pain and/or evoked pain in mSNA rats. "
02/23/2007 - "Here, in further rat studies, we report that systemic administration of ZD7288 reversed spontaneous pain induced by mild thermal injury (MTI) and tactile allodynia induced by SNL and MTI. "
01/01/2017 - "Blockade of Ih with selective antagonist, ZD7288 was able to eliminate the mechanical allodynia associated with cervical radiculopathic pain. "
06/04/2015 - "We found 7days after mSNA: (1) a significant increase in HCN2-immunoreactivity in small (<30μm) DRG neurons (predominantly IB4-negative neurons), and in the proportion of small neurons expressing HCN2 (putative nociceptors); (2) no significant change in HCN1- or HCN3-immunoreactivity in all cell types; and (3) attenuation, with ZD7288 (100μM intraplantar), of chronic spontaneous pain behavior (spontaneous foot lifting) and mechanical, but not, heat hypersensitivity. "
02/23/2007 - "An important locus of action appears to be in the skin since intraplantar (local) administration of ZD7288 completely suppressed tactile allodynia arising from MTI and SNL and reduced spontaneous pain due to MTI. "
5. Hypersensitivity (Allergy)

Related Drugs and Biologics

1. Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
2. Analgesics (Analgesic Drugs)
3. Acetaldehyde
4. adenosine-3',5'-cyclic phosphorothioate
5. protein kinase modulator
6. Ivabradine
7. Proteins (Proteins, Gene)
8. Cyclic Nucleotides
9. Purinergic P2X3 Receptors
10. Cyclic Nucleotide-Gated Cation Channels

Related Therapies and Procedures

1. Axotomy
2. Ligation
3. Spinal Injections
4. Injections