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hemoglobin P-Galveston

arginine replaces histidine at position 117(G19) of the beta chain

Also Known As:

Hb P-Galveston

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Hemoglobins: 37188
      - Abnormal Hemoglobins: 120
        hemoglobin P-Galveston: 2
  - Hemeproteins: 194
    - Globins: 2716
      - Hemoglobins: 37188
        Abnormal Hemoglobins: 120
        hemoglobin P-Galveston: 2

Related Diseases

1.	beta-Thalassemia (Cooley's Anemia) 08/01/1975 - "The mutant Hb P Galveston (beta117His leads to Arg) is observed in two heterozygotes for beta thalassemia and by itself does not cause clinical symptoms. " 08/01/1975 - "A Swiss family with hemoglobin P Galveston beta117His leads to Arg, including two patients with hb P/beta thalassemia."
2.	Hemoglobinopathies 06/01/1993 - "As an example of the use of these methods, we report the characterization of an unknown hemoglobinopathy case that was finally authenticated as Hb P-Galveston [beta 117(G19)His-->Arg], using the following sequence of analyses: 1) ESMS of complete hemolysate, 2) analytical HPLC of globin chains, 3) combined microbore HPLC/ESMS of globin chains to determine their molecular masses, 4) cysteine derivatization and tryptic digestion of mixture of all globins, followed by microbore separation of the peptides, molecular mass determination, and generation of fragmentation patterns allowing confirmation of amino acid sequences. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Globins
3.	Cysteine (L-Cysteine)
4.	hemoglobin P (Hb P)