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3- ethyl- 1- (6- hydroxy- 6- methylheptyl)- 7- propylxanthine

Also Known As:

A90 6119; A90-6119

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Xanthines: 123
    - 3-ethyl-1-(6-hydroxy-6-methylheptyl)-7-propylxanthine: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purinones: 2
        Xanthines: 123
        3-ethyl-1-(6-hydroxy-6-methylheptyl)-7-propylxanthine: 1

Related Diseases

1.	Ulcer 05/01/1993 - "These data suggest that the 3-ethylxanthine A90 6119 possesses pronounced anti-ulcer activity and that its repeated administration might not aggravate ulcer formation and might reduce the incidence of recurrence." 05/01/1993 - "When doses of cimetidine (200 mg/kg) and A90 6119 (10 mg/kg), equipotent in the water immersion stress model, were orally given twice daily for 5 consecutive days before the induction of gastric ulcers by stress, the H2-receptor antagonist aggravated significantly the ulcer formation while the xanthine derivative did not show such an effect. " 05/01/1993 - "The effects of the novel xanthine derivative 3-ethyl-1-(6-hydroxy-6-methylheptyl)-7-propylxanthine (A90 6119, CAS 134072-58-5) on various experimentally induced ulcers was investigated in rats. "
2.	Stomach Ulcer (Gastric Ulcer) 05/01/1993 - "A90 6119 produced a dose-dependent inhibition of gastric ulcers induced by water immersion stress and absolute ethanol with ED50- values of 2.4 and 2.8 mg/kg, p.o., respectively. " 05/01/1993 - "When doses of cimetidine (200 mg/kg) and A90 6119 (10 mg/kg), equipotent in the water immersion stress model, were orally given twice daily for 5 consecutive days before the induction of gastric ulcers by stress, the H2-receptor antagonist aggravated significantly the ulcer formation while the xanthine derivative did not show such an effect. "
3.	Hemorrhage 05/01/1993 - "Likewise, A90 6119 caused a dose-dependent inhibition of gastric erosions and intestinal hemorrhage induced by platelet activating factor (PAF) with ED50- values of 8.7 and 11.9 mg/kg p.o., respectively. "
4.	Duodenal Ulcer (Curling's Ulcer) 05/01/1993 - "Duodenal ulcer induced by cysteamine was also dose-dependently inhibited by A90 6119 with an ED50-value of 0.3 mg/kg, i.p. "

Related Drugs and Biologics

1.	3- ethyl- 1- (6- hydroxy- 6- methylheptyl)- 7- propylxanthine
2.	Xanthine
3.	Platelet Activating Factor
4.	Cysteamine (Mercaptamine)
5.	Cimetidine (Biomet)
6.	Ethanol (Ethyl Alcohol)