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7- benzylamino- 6- chloro- 2- piperazino- 4- pyrrolidinopteridine

inibits growth of B16 melanoma & MCF-7 mammary carcinoma cells

Also Known As:

DC-TA-46

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine: 5
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Pteridines: 147
      - 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine: 5

Experts

1.	Biagioni, Stefano: 1 article (01/2017)
2.	Cardarelli, Silvia: 1 article (01/2017)
3.	Cifone, Maria Grazia: 1 article (01/2017)
4.	Cinque, Benedetta: 1 article (01/2017)
5.	Galli, Francesca: 1 article (01/2017)
6.	Giardi, Maria Federica: 1 article (01/2017)
7.	Giorgi, Mauro: 1 article (01/2017)
8.	Massimi, Mara: 1 article (01/2017)
9.	Panera, Nadia: 1 article (01/2017)
10.	Ragusa, Federica: 1 article (01/2017)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 01/01/2017 - "The present study investigated the effects of two PDE4 inhibitors, rolipram and DC-TA-46, on the growth of human hepatoma HepG2 cells. "
2.	Carcinoma (Carcinomatosis) 01/01/1998 - "The carcinoma cell line CarB showed the highest sensitivity to DC-TA-46 (IC50 = 0.8 +/- 0.3 microM). " 07/01/1993 - "DC-TA-46 was found to inhibit growth of B16 melanoma and MCF-7 mammary carcinoma cells dose dependently (B16: IC50 = 1.7 microM, MCF-7: IC50 = 2 microM). "
3.	Neuroblastoma 01/01/2001 - "The effect of cyclic nucleotide phosphodiesterase (PDE) inhibitors Zaprinast and DC-TA-46 has been tested on SK-N-MC neuroblastoma growth. "
4.	Neoplasms (Cancer) 02/15/2002 - "DC-TA-46 inhibits cAMP-hydrolysis of PDE4 isolated from solid tumors of the human large cell lung tumor xenograft LXFL529 in the nanomolar range (IC(50)=16+/-5nM). "
5.	Experimental Melanoma 07/01/1993 - "DC-TA-46 was found to inhibit growth of B16 melanoma and MCF-7 mammary carcinoma cells dose dependently (B16: IC50 = 1.7 microM, MCF-7: IC50 = 2 microM). "

Related Drugs and Biologics

1.	Phosphodiesterase 4 Inhibitors
2.	Rolipram
3.	Phosphoric Diester Hydrolases (Phosphodiesterases)
4.	Cyclic Nucleotides
5.	zaprinast